Subgroup analysis: random-effects model of the risk of lower extremity amputation in people with diabetes associated with depression compared with no depression according to region (USA vs Europe) [IV=Inverse Variance]. Subgroup analysis: random-effects model of the risk of lower extremity amputation in people with diabetes associated with depression compared with no depression according to region (USA vs Europe) [IV=Inverse Variance]. Sinéad M O’Neill et al. BMJ Open Diab Res Care 2017;5:e000366 ©2017 by American Diabetes Association