Characterization of patients with cystic fibrosis presenting an indeterminate glucose tolerance (INDET) Adèle Coriati, Sophie Ziai, Mirna Azar, Yves.

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Characterization of patients with cystic fibrosis presenting an indeterminate glucose tolerance (INDET) Adèle Coriati, Sophie Ziai, Mirna Azar, Yves Berthiaume, Rémi Rabasa-Lhoret Journal of Cystic Fibrosis Volume 15, Issue 1, Pages 127-132 (January 2016) DOI: 10.1016/j.jcf.2015.03.001 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Plasma A) glucose and B) insulin excursions after a 1.75g of glucose/kg of a 2h-OGTT between glucose tolerance groups. Black dotted curve, normal glucose tolerance (NGT); black solid curve, de novo CF-related diabetes (CFRD); gray solid curve, impaired glucose tolerance (IGT); gray dotted curve, indeterminate glucose tolerance (INDET). (n=252 adult patients with CF in total). Two-way ANOVA with repeated measures to determine the interaction between tolerance groups and A) glucose or B) insulin plasma values during OGTT (P<0.001). Tolerance groups that do not share the same letter are statistically different from each other in which the P values represent the Mann–Whitney Student's T-Test (P<0.05). *: for the de novo CFRD curve. Data are represented as ±SEM. Journal of Cystic Fibrosis 2016 15, 127-132DOI: (10.1016/j.jcf.2015.03.001) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Disposition index: total insulin secretion index adjusted for insulin sensitivity index between glucose tolerance groups. AUC0–120 during OGTT reflects total insulin secretion index and insulin sensitivity index represent the Stumvoll index. NGT: normal glucose tolerance, INDET: indeterminate glucose tolerance, IGT: impaired glucose tolerance, CFRD: CF-related diabetes. n=252 adult patients with CF in total. Data are represented as ±SEM. Journal of Cystic Fibrosis 2016 15, 127-132DOI: (10.1016/j.jcf.2015.03.001) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Supplementary Fig. 1 Scattergram of measured forced expiratory volume in 1s as a percentage of predicted (%FEV1) against every glucose tolerance group in patients with CF. NGT: normal glucose tolerance, INDET: indeterminate glucose tolerance, IGT: impaired glucose tolerance, CFRD: CF-related diabetes. n=252 adult patients with CF in total. Medians are represented for each glucose tolerance group. Journal of Cystic Fibrosis 2016 15, 127-132DOI: (10.1016/j.jcf.2015.03.001) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions