Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p Jaume Mora, Nai-Kong V. Cheung,

Slides:

Advertisements

Similar presentations

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

Advertisements

Nine Novel Germline Gene Variants in the RET Proto-Oncogene Identified in Twelve Unrelated Cases Syed A. Ahmed, Karen Snow-Bailey, W. Edward Highsmith,

Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

Quantification of Parvovirus B19 DNA Using COBAS AmpliPrep Automated Sample Preparation and LightCycler Real-Time PCR Stefan Schorling, Gunnar Schalasta,

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Tylosis esophageal cancer locus on chromosome 17q25

Bone Marrow Transplant Engraftment Analysis with Loss of an Informative Allele Steven A. Schichman, Pei Lin, Lori J. Gilbrech, Pamela S. Gray, Carla S.

Statistical Considerations for Immunohistochemistry Panel Development after Gene Expression Profiling of Human Cancers Rebecca A. Betensky, Catherine.

Laila C. Schenkel, Charles Schwartz, Cindy Skinner, David I

Molecular Genetics of Pediatric Soft Tissue Tumors

Christos Sotiriou, Chand Khanna, Amir A

Da Eun Lee, Ji Hyae Lim, Min Hyoung Kim, So Yeon Park, Hyun Mee Ryu

Distinguishing de Novo Second Cancer Formation from Tumor Recurrence

Wanlong Ma, Hagop Kantarjian, Xi Zhang, Chen-Hsiung Yeh, Zhong J

Mutation Screening in Juvenile Polyposis Syndrome

Joanna Wang, Chetan Bettegowda The Journal of Molecular Diagnostics

Increased Sensitivity of the Roche COBAS AMPLICOR HCV Test, Version 2

Bile-Based Detection of Extrahepatic Cholangiocarcinoma with Quantitative DNA Methylation Markers and Its High Sensitivity So-Hyun Shin, Kyoungbun Lee,

Utilization of Whole-Exome Next-Generation Sequencing Variant Read Frequency for Detection of Lesion-Specific, Somatic Loss of Heterozygosity in a Neurofibromatosis.

Karin D. Berg, Cynthia L. Glaser, Richard E. Thompson, Stanley R

A Tumor Sorting Protocol that Enables Enrichment of Pancreatic Adenocarcinoma Cells and Facilitation of Genetic Analyses Zachary S. Boyd, Rajiv Raja,

Detecting 22q11.2 Deletions by Use of Multiplex Ligation-Dependent Probe Amplification on DNA from Neonatal Dried Blood Spot Samples Karina M. Sørensen,

Patrick R. Murray The Journal of Molecular Diagnostics

Detection of an Apparent Homozygous 3120G>A Cystic Fibrosis Mutation on a Routine Carrier Screen Denise LaMarche Heaney, Patrick Flume, Lauren Hamilton,

William L. Gerald, M.D., Ph.D, 1954–2008

Bone Marrow Transplant Engraftment Analysis with Loss of an Informative Allele Steven A. Schichman, Pei Lin, Lori J. Gilbrech, Pamela S. Gray, Carla S.

Kyong-Ah Yoon, Sohee Park, Sang Hee Lee, Jin Hee Kim, Jin Soo Lee

The Human Androgen Receptor X-Chromosome Inactivation Assay for Clonality Diagnostics of Natural Killer Cell Proliferations Michaël Boudewijns, Jacques.

Catherine E. Keegan, Anthony A. Killeen

Volume 26, Issue 2, Pages (February 2018)

SNPitty The Journal of Molecular Diagnostics

Molecular Aspects of Melanocytic Dysplastic Nevi

De Novo BRCA1 Mutation in a Patient with Breast Cancer and an Inherited BRCA2 Mutation Andrea Tesoriero, Chris Andersen, Melissa Southey, Gino Somers,

The c.1364C>A (p.A455E) Mutation in the CFTR Pseudogene Results in an Incorrectly Assigned Carrier Status by a Commonly Used Screening Platform Kristin.

Target-Enriched Next-Generation Sequencing Reveals Differences between Primary and Secondary Ovarian Tumors in Formalin-Fixed, Paraffin-Embedded Tissue

BRAF Mutation Testing in Solid Tumors

Reliable Transcript Quantification by Real-Time Reverse Transcriptase-Polymerase Chain Reaction in Primary Neuroblastoma Using Normalization to Averaged.

Multiplex Bead Suspension Array for Screening Neisseria gonorrhoeae Antibiotic Resistance Genetic Determinants in Noncultured Clinical Samples Sergey.

A Practical Approach to the Detection of Prognostically Significant Genomic Aberrations in Multiple Myeloma Zhong Chen, Bonnie Issa, Shiang Huang, Emily.

Eung Bae Lee, MD, Tae I. n Park, MD, PhD, Sun H

The Molecular Pathology of Primary Immunodeficiencies

Iris Schrijver, Tiffanee J. Lenzi, Carol D. Jones, Marla J

High Frequency of Loss of Heterozygosity on Chromosome Region 9p21–p22 but Lack of p16INK4a/p19ARF Mutations in Greek Patients with Basal Cell Carcinoma.

Genetic Heterogeneity in Saliva from Patients with Oral Squamous Carcinomas Adel K. El-Naggar, Li Mao, Gregg Staerkel, Madelene M. Coombes, Susan L. Tucker,

Detection and Discrimination between Deletional and Non-Deletional Prader-Willi and Angelman Syndromes by Methylation-Specific PCR and Quantitative Melting.

Molecular Diagnosis of Metastasizing Oligodendroglioma

A Multi-Exonic BRCA1 Deletion Identified in Multiple Families through Single Nucleotide Polymorphism Haplotype Pair Analysis and Gene Amplification with.

Multifocal Myxoid Liposarcoma—Metastasis or Second Primary Tumor?

Tylosis esophageal cancer locus on chromosome 17q25

A Novel Method for Creating Artificial Mutant Samples for Performance Evaluation and Quality Control in Clinical Molecular Genetics Michael Jarvis, Ramaswamy.

Genomic Technologies and the New Era of Genomic Medicine

Katy Hanlon, Lorna W. Harries, Sian Ellard, Claudius E. Rudin

A Novel Multiplexing, Polymerase Chain Reaction-Based Assay for the Analysis of Chromosome 18q Status in Colorectal Cancer Nadina Erill, Anna Colomer,

Rapid Polymerase Chain Reaction-Based Detection of Epidermal Growth Factor Receptor Gene Mutations in Lung Adenocarcinomas Qiulu Pan, William Pao, Marc.

A New Insertion/Deletion of the Cystic Fibrosis Transmembrane Conductance Regulator Gene Accounts for 3.4% of Cystic Fibrosis Mutations in Sardinia: Implications.

Triplet Repeat Primed PCR (TP PCR) in Molecular Diagnostic Testing for Friedreich Ataxia Paola Ciotti, Emilio Di Maria, Emilia Bellone, Franco Ajmar,

Use of Pyrosequencing of 16S rRNA Fragments to Differentiate between Bacteria Responsible for Neonatal Sepsis Jeanne A. Jordan, Allyson R. Butchko, Mary.

Karen Snow-Bailey, Ph.D., 1961–2006

KIT Gene Deletions at the Intron 10−Exon 11 Boundary in GI Stromal Tumors Christopher L. Corless, Laura McGreevey, Ajia Town, Arin Schroeder, Troy Bainbridge,

Clinical and Molecular Characterization of Patients at Risk for Hereditary Melanoma in Southern Brazil Patricia Ashton-Prolla, Lucio Bakos, Gerson Junqueira,

Judith L. Ross, David Roeltgen, Harvey Kushner, Fanglin Wei, Andrew R

Xiangfeng Cui, Helen Feiner, Honghua Li

Constitutional Mutations of the hSNF5/INI1 Gene Predispose to a Variety of Cancers Nicolas Sévenet, Eammon Sheridan, Daniel Amram, Pascale Schneider,

A Deletion Mutation in COL17A1 in Five Austrian Families with Generalized Atrophic Benign Epidermolysis Bullosa Represents Propagation of an Ancestral.

Nathan D. Montgomery, Sara R. Selitsky, Nirali M. Patel, D

Angiotensin I-Converting Enzyme

Monique A. Johnson, Marvin J. Yoshitomi, C. Sue Richards

Comparison of Genetic Profiles Between Primary Melanomas and their Metastases Reveals Genetic Alterations and Clonal Evolution During Progression Reiji.

Katharina Steinmann, Lan Kluwe, Reinhard E

Presentation transcript:

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p Jaume Mora, Nai-Kong V. Cheung, Brian H. Kushner, Michael P. LaQuaglia, Kim Kramer, Melissa Fazzari, Glenn Heller, Lishi Chen, William L. Gerald The Journal of Molecular Diagnostics Volume 2, Issue 1, Pages 37-46 (February 2000) DOI: 10.1016/S1525-1578(10)60613-7 Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Representative electrophoretic profiles of microsatellite marker products A: Retained heterozygosity. B: Loss of heterozygosity. C: Microsatellite mutation. N, germline allelotype; T, tumor allelotype. The Journal of Molecular Diagnostics 2000 2, 37-46DOI: (10.1016/S1525-1578(10)60613-7) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 LOH analysis for stage 4S patients. Approximate map location of polymorphic markers is shown at the left. Black boxesrepresent LOH, gray boxes are non-informative loci,white boxes are retained heterozygosity, and hatched boxes indicate microsatellite mutations. The Journal of Molecular Diagnostics 2000 2, 37-46DOI: (10.1016/S1525-1578(10)60613-7) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 3 Local-regional tumors with LOH at diagnosis. Approximate map location of polymorphic markers is shown at the left. Shading highlights the region of potential loss at 1p36, the most commonly deleted area, and defines the shortest region of overlap. Black boxesrepresent LOH, gray boxes are non-informative loci,white boxes are retained heterozygosity, and hatched boxes indicate microsatellite mutations. The Journal of Molecular Diagnostics 2000 2, 37-46DOI: (10.1016/S1525-1578(10)60613-7) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 4 Stage 4 tumors at diagnosis with LOH involving shortest region of overlap on 1p36. Approximate map location of polymorphic markers is shown at the left. Shading highlights the region of potential loss within 1p36 and defines the shortest region of overlap. Black boxes represent LOH, gray boxes are non-informative loci, white boxes are retained heterozygosity, and hatched boxes indicate microsatellite mutations. The Journal of Molecular Diagnostics 2000 2, 37-46DOI: (10.1016/S1525-1578(10)60613-7) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 5 Stage 4 tumors at diagnosis with LOH involving shortest region of overlap on 1p22. Approximate map location of polymorphic markers is shown at the left. Shading highlights the region of potential loss within 1p22 and defines the shortest region of overlap. Black boxes represent LOH, gray boxes are non-informative loci, white boxes are retained heterozygosity, and hatched boxes indicate microsatellite mutations. The Journal of Molecular Diagnostics 2000 2, 37-46DOI: (10.1016/S1525-1578(10)60613-7) Copyright © 2000 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions