Placental Malaria: From Infection to Malfunction

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Presentation transcript:

Placental Malaria: From Infection to Malfunction Luciana Vieira de Moraes, Carlos Penha-Gonçalves Cell Host & Microbe Volume 13, Issue 2, Pages 125-127 (February 2013) DOI: 10.1016/j.chom.2013.01.014 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Plasmodium Infection and Placenta Malfunction Accumulation of infected erythrocytes (IE) in maternal blood spaces (MBS) leads to inflammatory mononuclear cell recruitment. In this inflammatory mellieu C5a proinflammatory activity contributes to imbalance of angiogenic factors. As a result of this antiangiogenic response, intraplacental vascular resistance increases impairing placental perfusion. Altered hemodynamics in the infected placenta conditions maternal blood flow, which promotes infected erythrocyte accumulation. This cycle amplifies the inflammatory response leading to placental dysfunction and impacting fetal growth. Therapeutic intervention aiming to decrease C5a generation/signaling could contribute to promote a proangiogenic response and restore placental perfusion counteracting the deleterious effects of placental malaria in the pregnancy outcome. Cell Host & Microbe 2013 13, 125-127DOI: (10.1016/j.chom.2013.01.014) Copyright © 2013 Elsevier Inc. Terms and Conditions