Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles Jan.

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Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles Jan W. Balder, BSc, Jeroen K. de Vries, MD, Ilja M. Nolte, PhD, Peter J. Lansberg, MD, PhD, Jan A. Kuivenhoven, PhD, Pieter W. Kamphuisen, MD, PhD Journal of Clinical Lipidology Volume 11, Issue 4, Pages 1055-1064.e6 (July 2017) DOI: 10.1016/j.jacl.2017.05.007 Copyright © 2017 National Lipid Association Terms and Conditions

Figure 1 Outline of exclusion route. This figure shows how many and for which reasons participants were excluded. In total 18,640 individuals (12%) were excluded. CVD, cardiovascular disease; LLD, lipid-lowering drugs. Journal of Clinical Lipidology 2017 11, 1055-1064.e6DOI: (10.1016/j.jacl.2017.05.007) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 2 Relations between age and levels of total cholesterol, LDL-C, and calculated LDL-C in men and women. The 5th, 10th, 25th, 50th, 75th, 90th and 95th age-specific percentile curves for total cholesterol, LDL-C, and calculated LDL-C (using Friedewald formula) in men (left) and women (right). LDL-C, low-density lipoprotein cholesterol. Journal of Clinical Lipidology 2017 11, 1055-1064.e6DOI: (10.1016/j.jacl.2017.05.007) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 3 Relations between age and levels of HDL-C and triglycerides in men and women. The 5th, 10th, 25th, 50th, 75th, 90th and 95th age-specific percentile curves for HDL-C and triglycerides in men (left) and women (right). HDL-C, high-density lipoprotein cholesterol. Journal of Clinical Lipidology 2017 11, 1055-1064.e6DOI: (10.1016/j.jacl.2017.05.007) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 4 Comparing levels of total cholesterol, LDL-C, and triglycerides as measured in the LRC Prevalence study, the AHA special report, and the Lifelines study. The 5th, 25th, 50th, 75th, and 95th age-specific percentile curves for total cholesterol, LDL-C, and triglycerides are presented for the LRC Prevalence study (solid line),12 the AHA special report (dotted line),13 and Lifelines study (interrupted line), in men and women. LDL-C levels from Prevalence study and AHA special report were similar. LDL-C, low-density lipoprotein cholesterol; LRC, Lipid Research Clinics; AHA, American Heart Association. Journal of Clinical Lipidology 2017 11, 1055-1064.e6DOI: (10.1016/j.jacl.2017.05.007) Copyright © 2017 National Lipid Association Terms and Conditions

Supplementary Figure 1 Absolute difference in calculated Friedewald LDL-C and direct LDL-C measurement by triglyceride strata. The absolute difference between Friedewald LDL-C and direct measurement of LDL-C by triglyceride strata are presented as median (circles) and the 5th and 95th percentile (error bars), separately for men (black) and women (white). Values below zero indicate that the direct measurement is higher than the Friedewald calculation and vice versa. To convert cholesterol parameters to mmol/L, multiply values by 0.02586. To convert triglycerides to mmol/L, multiply by 0.0113. Journal of Clinical Lipidology 2017 11, 1055-1064.e6DOI: (10.1016/j.jacl.2017.05.007) Copyright © 2017 National Lipid Association Terms and Conditions