Brian T Feeley, BS, Aric K Park, BS, Sophoclis Alexopoulos, BS, E

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Pressure delivery of AS-ICAM-1 ODN with LFA-1 mAb reduces reperfusion injury in cardiac allografts Brian T Feeley, BS, Aric K Park, BS, Sophoclis Alexopoulos, BS, E.Grant Hoyt, Michael P Ennen, BS, Robert S Poston, MD, Robert C Robbins, MD The Annals of Thoracic Surgery Volume 68, Issue 1, Pages 119-124 (July 1999) DOI: 10.1016/S0003-4975(99)00503-2

Fig 1 Histograms depicting the effects of ex vivo hyperbaric pressure administration of AS-ICAM-1 ODN and systemic anti-LFA-1 mAb on reperfusion injury. (A) Percent wet weight analysis measuring cardiac edema shows a decrease with treated groups over saline controls. (B) Myeloperoxidase activity assaying for neutrophil infiltration in the allograft demonstrates that combination treatment had the greatest blockade of neutrophil infiltration. (C) Contraction band necrosis percentage to measure histologic damage shows a significant decrease in allograft damage in all treated groups. (D) Heart scores demonstrating that all groups had satisfactory allograft function. ∗ = p< 0.05 compared to saline controls. The Annals of Thoracic Surgery 1999 68, 119-124DOI: (10.1016/S0003-4975(99)00503-2)

Fig 2 Photomicrographs of allograft sections taken 24 hours after transplantation. Saline controls (A) show significant contraction band necrosis (arrows). Treatment with AS-ICAM-1 ODN (B), anti-LFA-1 mAb (C), or both (D), achieved a decrease in contraction band necrosis. The Annals of Thoracic Surgery 1999 68, 119-124DOI: (10.1016/S0003-4975(99)00503-2)

Fig 3 Immunohistochemistry analysis of ICAM-1 protein expression. ICAM-1 protein stains brown in the sections. (A) Saline control shows high levels of expression of ICAM-1, especially around vessels (arrow). (B) Treatment with AS-ICAM-1 ODN decreases ICAM-1 expression. (C) Combination of AS-ICAM-1 ODN and LFA-1 mAb shows similar ICAM-1 expression as (B). The Annals of Thoracic Surgery 1999 68, 119-124DOI: (10.1016/S0003-4975(99)00503-2)