DNA Replication/ Regeneration

Goal of DNA Replication Makes an _________ copy of itself (Needed for new cells produced during Mitosis)

Goal of DNA Replication Why do we need new cells? _________ Repair & _________ REGENERATION

Regeneration Regeneration of a lost limb 1. De-differentiation of adult cells to stem cells 2. Development of stem cells into new tissue

When does it take place? Regeneration/ Replication of new _________ takes place during the _________ cycle S Phase of _________ (Mitosis)

The Process of DNA Replication 1. _________ 2. _________ 3. _________ 4. _________________ 5. _________

Step 1: _________ Enzyme: _________ strand uncoils DNA _________ unwinds it

Step 2: Unzipping DNA strands breaks in half (unzips) _________ bonds are broken Enzyme: DNA helicase breaks _________ bonds

“Y” formation known as replication fork Step 2: continued “Y” formation known as replication fork

Step 3: Adding New Parts Enzyme: DNA _________ matches original DNA strand with complementary base pairs using free nucleotides

Step 3: Adding New Parts

Step 3: Adding New Parts Proofreading Enzyme: DNA Polymerase can “backtrack” and _________ any mistakes that are made DNA polymerase will make a mistake about 1 out of every _________ free nucleotides it matches

Step 4: Two DNA molecules Final product: 2 _________ DNA strands One set of DNA for each cell

Step 5: Recoil DNA strand winds back up into a _________ _________

DNA Replication Entire chromosome can be replicated in about 8 hours

The Future of DNA Replication/ Regeneration Humans capable of regenerating nerve cells (cure paralysis)? Regenerating new skin cells (slow the aging process)? Humans capable of regenerating lost limbs (combining lizard DNA with humans)? Dr. Connors