Re-evaluation of the Blood-Brain Barrier in the Presence of Alzheimer’s Disease Pathology  Jason D. Ulrich, Tien-Phat Huynh, David M. Holtzman  Neuron  Volume 88, Issue 2, Pages 237-239 (October 2015) DOI: 10.1016/j.neuron.2015.10.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 The Integrity of the BBB in Health and Disease (A) Diagram of the neurovascular unit. (B) A healthy BBB greatly restricts entry of plasma proteins such as IgGs into the brain. (C) During inflammatory conditions such as EAE or LPS administration, there is a pronounced increase in BBB permeability correlating with breakdown of tight junctions and a resulting increase in IgG penetrance into the brain. (D) In the setting of AD pathology, the BBB remains largely intact and restricts the entry of plasma proteins, including IgG, into the brain. (E) Amyloid deposition in the vasculature during CAA can weaken vessel integrity and damage the BBB, resulting in increased microhemorrhages, and may influence the infiltration of IgG and many other proteins into the brain. Neuron 2015 88, 237-239DOI: (10.1016/j.neuron.2015.10.008) Copyright © 2015 Elsevier Inc. Terms and Conditions