Carriage of resistant pneumococci by children in southern Israel and impact of conjugate vaccines on carriage Ron Dagan, Drora Fraser, Noga Givon, Pablo.

Slides:

Advertisements

Similar presentations

Laboratory diagnosis and biosafety issues of biological warfare agents

Advertisements

Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread.

Changes in antimicrobial resistance, serotypes and genotypes in Streptococcus pneumoniae over a 30-year period J. Liñares, C. Ardanuy, R. Pallares, A.

Grepafloxacin: microbiological properties

Approach to diagnosis of infective endocarditis

Impact of the emergence of non-vaccine pneumococcal serotypes on the clinical presentation and outcome of adults with invasive pneumococcal pneumonia

Herpes zoster in non-hospitalized children

Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era S. Nunes,

Assessment of Streptococcus pneumoniae pilus islet-1 prevalence in carried and transmitted isolates from mother–infant pairs on the Thailand–Burma border

Use of antimicrobials and resistance in bacteria isolated from blood cultures in a Danish county from 1992 to 1995 Thomas Lund S⊘rensen, Niels Frimodt-M⊘ller,

Antimicrobial resistance of nasopharyngeal pneumococci from children from day-care centres and orphanages in Russia: results of a unique prospective multicentre.

Bernard Grenier Clinical Microbiology and Infection

Didier Guillemot, Claude Carbon Clinical Microbiology and Infection

Current patterns and evolution of antibiotic resistance among bacterial pathogens involved in acute otitis media Fernando Baquero, Rafael Cantón, Fernando.

Link between intracellular pathogens and cardiovascular diseases

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Hexavalent vaccines for immunization in paediatric age

Carriage and antibiotic resistance of respiratory pathogens and molecular epidemiology of antibiotic-resistant Streptococcus pneumoniae colonizing children.

How to evaluate and predict the epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach D. Guillemot Clinical Microbiology.

Holt Hanne M. , Søgaard Per , Gahrn-Hansen Bente

Serotypes, biotypes and antimicrobial susceptibilities of Haemophilus influenzae isolated from invasive disease in children in Casablanca N. Moustaoui,

Invasive pneumococcal disease among children in a health district of Barcelona: early impact of pneumococcal conjugate vaccine E. Calbo, Á. Díaz, E.

Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era S. Nunes,

Structure of grepafloxacin relative to activity and safety profile

D.E. Low Clinical Microbiology and Infection

Prevalence of pilus-encoding islets among acute otitis media Streptococcus pneumoniae isolates from Israel M. Moschioni, G. De Angelis, S. Melchiorre,

The role of vaccination in preventing pneumococcal disease in adults

The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci Keith Klugman, Fred Goldstein,

C-3′Quaternary Ammonium Cephems, a New Wave of Cephalosporins

Sofie Arens, Jan Verhaegen, Ludo Verbist

Training for the infectious diseases speciality in Norway

Rotavirus vaccination: a concise review

G. Höffken Clinical Microbiology and Infection

Laboratory diagnosis and biosafety issues of biological warfare agents

Haemophilus influenzae serotype b conjugate vaccine failure in twelve countries with established national childhood immunization programmes S. Ladhani,

Antibiotic usage and the incidence of resistance

Development and testing of Streptococcus pneumoniae conjugate vaccines

André Bryskier Clinical Microbiology and Infection

Decreasing rates of resistance to penicillin, but not erythromycin, in Streptococcus pneumoniae after introduction of a policy to restrict antibiotic.

Isolation rate, T-serotyping and susceptibility to antibiotics of Group A Streptococcus from pediatric infections in Athens* M. Kanellopoulou, A. Makri,

Experience with pneumococcal polysaccharide conjugate vaccine (conjugated to CRM197 carrier protein) in children and adults* P. Durando, S.N. Faust,

Laboratory diagnosis of Clostridium difficile disease

Ecological effects on the oro- and nasopharyngeal microflora in children after treatment of acute otitis media with cefuroxime axetil or amoxycillin-clavulanate.

T.M. File Clinical Microbiology and Infection

Role of communicable disease control measures in affecting the spread of resistant pneumococci: the Swedish model Karl Ekdahl, Otto Cars Clinical Microbiology.

Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media;

Community-acquired pneumonia: epidemiologic and clinical consideration

Grepafloxacin: pharmacokinetics and tissue penetration

Changes in Streptococcus pneumoniae serotypes causing invasive disease with non- universal vaccination coverage of the seven-valent conjugate vaccine

Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal.

F. Schaumburg, B. Biallas, E. Ngoune Feugap, A. S. Alabi, B

Circulation of international clones of levofloxacin non-susceptible Streptococcus pneumoniae in Taiwan Y.-C. Hsieh, L.-Y. Chang, Y.-C. Huang, H.-C. Lin,

Definition of the Clinical Antibacterial Spectrum of Activity

Clinical infection services—the Leiden experience

Ethan Rubinstein, Itzhak Levy Clinical Microbiology and Infection

Clinical Microbiology and Infection

W. Eugene Sanders, Christine C. Sanders

Overview of cefixime use in community-acquired infections

Facilitating learning and change in physicians: Implications for a system of continuing medical education in Europe Robert D. Fox Clinical Microbiology.

Abstracts Clinical Microbiology and Infection

New oral cephalosporins in pediatric community-acquired infections

Modification of prescribers’ behavior: the Icelandic approach

Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group† H. Goossens Clinical.

N. Markeas, G. Stamos, I. Paraskakis, A. Giokas, G. Pistevos

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

The DUEL study: a multi-center in vitro evaluation of linezolid compared with other antibiotics in the Netherlands J.W. Mouton, A.R. Jansz Clinical.

Impact of antibiotic restrictions: the patient's perspective

Decision-making in otitis media in children, Part I: epidemiologic data and definitions for a reliable cost-effectiveness analysis Bernard Grenier Clinical.

Fernando Baquero, John F

Presentation transcript:

Carriage of resistant pneumococci by children in southern Israel and impact of conjugate vaccines on carriage Ron Dagan, Drora Fraser, Noga Givon, Pablo Yagupsky Clinical Microbiology and Infection Volume 5, Pages 4S29-4S37 (August 1999) DOI: 10.1111/j.1469-0691.1999.tb00854.x Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Nasopharyngeal carriage of S. pneumoniae in healthy Jewish infants in Beer-Sheva at ages 2–24 months. (adapted from Dagan et al [18]) Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Nasopharyngeal carriage of S. pneumoniae and antibiotic-resistant S. pneumoniae by day-care attendance and the number of children per day care group, during the second year of life in southern Israel. (adapted from Dagan et al [18]) Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 Proportion of isolates from nasopharynx of healthy Jewish children compared with those isolated from middle ear fluid in children with acute otitis media, by age group. R, resistance; Pen-NS, penicillin non-susceptible; AOM, acute otitis media; NP, nasopharynx. Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 4 Effect of 23-valent non-conjugate, one-dose seven-valent conjugate (Pnc-OMP×1) and seven-valent two-dose conjugate (Pnc-OMPC×2) vaccine on carriage of S. pneumoniae and resistant S, pneumoniae in children aged 12–18 months. VT, serotypes included in the vaccine. (adapted from Austrian [32]) Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 5 The effect of a tetravalent (6B, 14, 19F and 23F) pneumococcal vaccine (either conjugated to tetanus toxoid (Pnc-T), or conjugated to diphtheria toxoid (Pnc-D)) on carriage of S. pneumoniae of the serotypes included in (6B, 14, 19F, 23F) or related to (6A) the vaccines, compared with placebo effect. VT, serotypes included in the vaccine. Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 6 Effect of a nine-valent conjugate vaccine on the nasopharyngeal carriage of S. pneumoniae of the serotypes included in the vaccine (A), of antibiotic-resistant S. pneumoniae (B), of total S. pneumoniae (C), and of S. pneumoniae of other serotypes not included in the vaccine (D), in 132 children, compared with 132 receiving control vaccine. Children were 12–35 months of age. At each determination, 66–132 children were examined. Clinical Microbiology and Infection 1999 5, 4S29-4S37DOI: (10.1111/j.1469-0691.1999.tb00854.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions