Volume 12, Issue 6, Pages (June 2013)

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Volume 12, Issue 6, Pages 546-553 (June 2013) Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial Prof P David Adelson, MD, Prof Stephen R Wisniewski, PhD, John Beca, MD, S Danielle Brown, MS, Michael Bell, MD, Prof J Paul Muizelaar, Pamela Okada, MD, Sue R Beers, PhD, Goundappa K Balasubramani, PhD, Deborah Hirtz, MD The Lancet Neurology Volume 12, Issue 6, Pages 546-553 (June 2013) DOI: 10.1016/S1474-4422(13)70077-2 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile Patients could have been excluded for more than one of the listed reasons. GCS=Glasgow coma scale. GMS= Glasgow motor score. TBI=traumatic brain injury. *Before expansion of inclusion criteria to patients older than 16 years but younger than 18 years on Feb 1, 2010. The Lancet Neurology 2013 12, 546-553DOI: (10.1016/S1474-4422(13)70077-2) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Outcomes at 3 months after injury Outcomes in terms of Glasgow outcome scale (GOS; A) and GOS-extended paediatrics (GOS-E Peds; B). A GOS of 5 and a GOS-E Peds of 8 corresponds to mortality; a score of 1 corresponds to normal functioning for both measures. p values are for comparison between therapeutic hypothermia and normothermia. The Lancet Neurology 2013 12, 546-553DOI: (10.1016/S1474-4422(13)70077-2) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Temperatures of patients during the first 5 days after randomisation Error bars are SDs. The Lancet Neurology 2013 12, 546-553DOI: (10.1016/S1474-4422(13)70077-2) Copyright © 2013 Elsevier Ltd Terms and Conditions