Mrinal K. Sarkar, Parames C. Sil Pathophysiology

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Presentation transcript:

Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity Mrinal K. Sarkar, Parames C. Sil Pathophysiology Volume 14, Issue 2, Pages 113-120 (October 2007) DOI: 10.1016/j.pathophys.2007.08.001 Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 (a). Effect of the protein isolate on cell viability in isolated hepatocytes treated with TAA as well as (b) on ALT and (c) LDH leakages. Results have been given as percentage of control. Control: hepatocytes were treated with DMEM, TAA: hepatocytes exposed to TAA (2mM) for 60min. P1+TAA, P2+TAA, P3+TAA and P4+TAA: hepatocytes incubated with protein isolate (10, 25, 50 and 100μg/ml) prior to TAA administration for 60min, vitamin C+TAA: hepatocytes first incubated with vitamin C and then with TAA. Each value represents mean±S.D. (Pa<0.05; Pb<0.05). Pathophysiology 2007 14, 113-120DOI: (10.1016/j.pathophys.2007.08.001) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Effect of the protein isolate on MDA levels in hepatocytes treated with TAA. Results have been given as percentage over control. Control: hepatocytes treated with DMEM, TAA: hepatocytes exposed to TAA (2mM) for 60min. P1+TAA, P2+TAA, P3+TAA and P4+TAA: hepatocytes incubated with protein isolate (10, 25, 50 and 100μg/ml) prior to TAA administration for 60min, vitamin C+TAA: hepatocytes first incubated with vitamin C and then with TAA. Each value represents mean±S.D. (Pa<0.05; Pb<0.05). Pathophysiology 2007 14, 113-120DOI: (10.1016/j.pathophys.2007.08.001) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Effect of the protein isolate on GSH levels in hepatocytes. Results have been given as percentage of control. Control: hepatocytes treated with DMEM, TAA: hepatocytes exposed to TAA (2mM) for 60min. P1+TAA, P2+TAA, P3+TAA and P4+TAA: hepatocytes incubated with protein isolate (10, 25, 50 and 100μg/ml) prior to TAA administration for 60min, vitamin C+TAA: hepatocytes first incubated with vitamin C and then with TAA. Each value represents mean±S.D. (Pa<0.05; Pb<0.05). Pathophysiology 2007 14, 113-120DOI: (10.1016/j.pathophys.2007.08.001) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 (a). Effect of the protein isolate on catalase, (b) SOD and (c) GST activity in hepatocytes. Results have been given as percentage of control. Control: hepatocytes treated with DMEM, TAA: hepatocytes exposed to TAA (2mM) for 60min. P1+TAA, P2+TAA, P3+TAA and P4+TAA: hepatocytes incubated with protein isolate (10, 25, 50 and 100μg/ml) prior to TAA administration for 60min, vitamin C+TAA: hepatocytes first incubated with vitamin C and then with TAA. Each value represents mean±S.D. (Pa<0.05; Pb<0.05). Pathophysiology 2007 14, 113-120DOI: (10.1016/j.pathophys.2007.08.001) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 DPPH scavenging activity of the protein isolate of Phyllanthus niruri with increasing concentrations. Pathophysiology 2007 14, 113-120DOI: (10.1016/j.pathophys.2007.08.001) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions