Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography.

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Presentation transcript:

Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study L. Laaksonen, M. Kallioinen, J. Långsjö, T. Laitio, A. Scheinin, J. Scheinin, K. Kaisti, A. Maksimow, R.E. Kallionpää, V. Rajala, J. Johansson, O. Kantonen, M. Nyman, S. Sirén, K. Valli, A. Revonsuo, O. Solin, T. Vahlberg, M. Alkire, H. Scheinin British Journal of Anaesthesia Volume 121, Issue 1, Pages 281-290 (July 2018) DOI: 10.1016/j.bja.2018.04.008 Copyright © 2018 The Author(s) Terms and Conditions

Fig 1 Study design, sequence of events and timing of measurements and blood samples. EC50 for LOR, Effective concentration 50 for loss of responsiveness; MACLOR, minimum alveolar concentration for LOR; [18F]FDG, 18F-labeled fluorodeoxyglucose; CMRglu, cerebral metabolic rate of glucose; PET, positron emission tomography. British Journal of Anaesthesia 2018 121, 281-290DOI: (10.1016/j.bja.2018.04.008) Copyright © 2018 The Author(s) Terms and Conditions

Fig 2 Boxplots of regional cerebral metabolic rate of glucose (CMRglu) in the 15 analysed regions of interest (ROIs) during dexmedetomidine, propofol, sevoflurane, S-ketamine, and placebo administration in 160 healthy subjects (P<0.001 between the treatments in all ROIs). Lowest CMRglu values were observed in the dexmedetomidine group (for paired comparisons, see Table 3). Boxes represent lower quartiles, medians and upper quartiles, whiskers represent 1.5×inter-quartile ranges below and above the lower and upper quartiles, respectively. Outlying values are marked with symbols. British Journal of Anaesthesia 2018 121, 281-290DOI: (10.1016/j.bja.2018.04.008) Copyright © 2018 The Author(s) Terms and Conditions

Fig 3 Boxplots of whole brain cerebral metabolic rate of glucose (CMRglu) in 160 healthy subjects. CMRglu was 63%, 71%, 71%, and 96% of placebo, in the dexmedetomidine, propofol, sevoflurane, and S-ketamine groups, respectively (P<0.001 between the groups). Dexmedetomidine differed from all other groups (for paired comparisons, see Table 3). Boxes represent lower quartiles, medians and upper quartiles, whiskers represent 1.5×inter-quartile ranges below and above the lower and upper quartiles, respectively. Outlying values are marked with symbols. British Journal of Anaesthesia 2018 121, 281-290DOI: (10.1016/j.bja.2018.04.008) Copyright © 2018 The Author(s) Terms and Conditions

Fig 4 Correlation plots of the associations between the mean measured drug concentration of dexmedetomidine, propofol, and S-ketamine and whole brain cerebral metabolic rate of glucose (CMRglu). r=Pearson correlation coefficient; dashed lines depict the 95% confidence intervals for the regression lines. British Journal of Anaesthesia 2018 121, 281-290DOI: (10.1016/j.bja.2018.04.008) Copyright © 2018 The Author(s) Terms and Conditions