Therapeutic angiogenesis induced by local autologous bone marrow cell implantation Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata,

Slides:

Advertisements

Similar presentations

Therapeutic Effect of Midkine on Cardiac Remodeling in Infarcted Rat Hearts Shinya Fukui, MD, Satoru Kitagawa-Sakakida, MD, PhD, Sin Kawamata, MD, PhD,

Advertisements

Therapeutic angiogenesis with intramyocardial administration of basic fibroblast growth factor Michio Kawasuji, MD, Hiroshi Nagamine, MD, Masahiro Ikeda,

Therapeutic angiogenesis using autologous bone marrow stromal cells: improved blood flow in a chronic limb ischemia model Abdulaziz Al-Khaldi, MD, Hilal.

Cell Physiol Biochem 2016;40: DOI: /

Jack H. Boyd, MD, Vedant S. Pargaonkar, MD, David H

Cardiomyocyte transplantation does not reverse cardiac remodeling in rats with chronic myocardial infarction Yutaka Sakakibara, MD, Keiichi Tambara,

Comparative effects of mesenchymal progenitor cells, endothelial progenitor cells, or their combination on myocardial infarct regeneration and cardiac.

Valavanur A Subramanian, John C McCabe, Charles M Geller

Hybrid Surgical Angiogenesis: Omentopexy Can Enhance Myocardial Angiogenesis Induced by Cell Therapy Taro Kanamori, MD, Go Watanabe, MD, Tamotsu Yasuda,

Coronary artery bypass grafting on the beating heart evaluated with integrated backscatter Kenichi Imasaka, MD, Shigeki Morita, MD, Ichiro Nagano, MD,

Long-term efficacy and safety of the intramyocardial implantation of autologous bone marrow cells for the treatment of ischemic heart disease Tao-Sheng.

The reduction of hemodynamic loading assists self-regeneration of the injured heart by increasing cell proliferation, inhibiting cell apoptosis, and inducing.

Coronary artery bypass grafting with gastroepiploic artery composite graft Toru Sato, MD, Tadashi Isomura, MD, Hisayoshi Suma, MD, Taiko Horii, MD, Norio.

Eosinophilic heart disease with vasculitis: supported by HeartMate left ventricular assist device and heart transplantation Chiao-Po Hsu, MD, Shiao-Hwang.

Intracoronary Shunt Prevents Ischemia in Off-Pump Coronary Artery Bypass Surgery Jacob Bergsland, MD, Per Snorre Lingaas, MD, Helge Skulstad, MD, PhD,

Single-Trunk Anomalous Origin of Both Coronary Arteries From Pulmonary Artery: Serendipitous Diagnosis and Successful Surgical Treatment Changwei Zhang,

Off-pump coronary operation at the Favaloro Foundation: results in 264 patients Ernesto E Weinschelbaum, MD, Alejandro Machain, MD, Héctor A Raffaelli,

Hartmuth B Bittner, MD The Annals of Thoracic Surgery

Takotsubo Cardiomyopathy After Coronary Intervention Developed During Hospitalization Jamal Hussain, MD, Nathan Laufer, MD, Suzane Sorrof, MD, Ashish.

Hiroshi Takami, MD, Taizo Hiraishi, MD, Tohru Kobayashi, MD

CD133+ cells: How could they have an IMPACT?

Endothelial Cell-Seeded Bovine Internal Mammary Artery for Complete Revascularization Pascal M. Dohmen, MD, PhD, Davide Gabbieri, MD, Alexander Lembcke,

Ventricular septal rupture caused by myocardial bridging

Improved Myocardial Perfusion and Thickening After Off-Pump Revascularization: 5- Year Follow-Up Chang Young Kim, MD, Ho Young Hwang, MD, Jin Chul Paeng,

Pravastatin Improves Remodeling and Cardiac Function After Myocardial Infarction by an Antiinflammatory Mechanism Rather than by the Induction of Angiogenesis

Michael D. Fridman, MD, Carl Y. Owada, MD, FACC, Richard D

Myocardial tactile stiffness during acute reduction of coronary blood flow Kagami Miyaji, MD, Seiryo Sugiura, MD, Hirotaka Inaba, MD, Shinichi Takamoto,

Patrick H McNulty, MD, Ian C Gilchrist, MD

Randomized Study of Mononuclear Bone Marrow Cell Transplantation in Patients With Coronary Surgery Qiang Zhao, MD, Yongxin Sun, MD, Limin Xia, MD, Anqing.

Therapeutic Potential of Human Umbilical Cord Derived Stem Cells in a Rat Myocardial Infarction Model Kai Hong Wu, MD, PhD, Bin Zhou, PhD, Cun Tao Yu,

Effects of Intra-Aortic Balloon Pumping on Graft Flow in Coronary Surgery: An Intraoperative Transit-Time Flowmetric Study Yoshiyuki Takami, MD, Hiroshi.

Myocardial revascularization with the posterior tibial artery

High-Dose Isosorbide Dinitrate for Myocardial Revascularization With Composite Arterial Grafts Jacob Gurevitch, MD, Hylton I Miller, MB, Itzhak Shapira,

Cardiac dysfunction induced by experimental myocardial infarction impairs the host defense response to bacterial infection in mice because of reduced.

Surgical myocardial revascularization without cardiopulmonary bypass

The coronary artery bypass conduit: II

Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis Masayuki Kubo, PhD, Tao-Sheng Li, MD, PhD, Takahiro.

Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation Shinji Tomita, MD, PhD, Donald.

Konno procedure for infective endocarditis involving aortic valve in a small child Kazutomo Goh, MD, Hiroshi Yamamoto, MD, Naoya Tsuda, MD, Tadahiro Sasajima,

Intraoperative evaluation of coronary anastomosis by transit-time ultrasonic flow measurement Tetsuro Morota, MD, PhD, Francis G Duhaylongsod, MD, William.

Single coronary artery and complete transposition of the great arteries: a technical challenge resolved? Vinayak Shukla, Robert M Freedom, MD, Michael.

Munir Boodhwani, MD, William E

Efficacy of Therapeutic Angiogenesis by Intramyocardial Injection of pCK-VEGF165 in Pigs Jae-Sung Choi, MD, PhD, Ki-Bong Kim, MD, PhD, Woong Han, DVM,

Up-regulation of vascular endothelial growth factor mrna and angiogenesis after transmyocardial laser revascularization Keith A Horvath, MD, Elaine Chiu,

Congenital Bilateral Coronary-to-Pulmonary Artery Fistulas

Ischemic preconditioning does not improve myocardial preservation during off-pump multivessel coronary operation Hannu J Penttilä, MD, Martti V.K Lepojärvi,

Elimination of Ischemic Mitral Regurgitation Does Not Alter Long-Term Left Ventricular Remodeling in the Ovine Model Kanji Matsuzaki, MD, PhD, Masato.

Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation Yutaka.

Off-pump coronary bypass grafting: how to use the octopus tissue stabilizer ErikW.L Jansen, MD, PhD, JaapR Lahpor, MD, PhD, Cornelius Borst, MD, PhD,

A man with saphenous vein graft aneurysms after bypass surgery

Iatrogenic Lesion of an Anomalous Circumflex Coronary Artery During Mitral Surgery Ana Lopez-Marco, MD, Aidil Syed, MD, Tom Combellack, MD, Dheeraj Mehta,

Ventriculocoronary artery bypass results using a mesh-tipped device in a porcine model Robert W Emery, MD, Frazier Eales, MD, Clifford H Van Meter, MD,

Ricardo P. J. Budde, PhD, Patricia F. A

Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia Murray.

M.Keith Odayan, Hugh S Paterson The Annals of Thoracic Surgery

Vassilios Gulielmos, Michael Knaut, Florian M. Wagner, Stephan Schüler

Raymond Cartier, MD, Robert Blain, MD The Annals of Thoracic Surgery

Massimo Bonacchi, MD, Edvin Prifti, MD, PhD, Gabriele Giunti, MD

Peter Pecher, MD, Bernd A Schumacher, MD

Richard Lee, Takashi Nitta, Ralph A. Schmid, Richard B

Staged Therapeutic Approach in Spontaneous Coronary Dissection

Reversibility of Cardiac Dysfunction After Valve Replacement in Elderly Patients With Severe Aortic Stenosis Masafumi Natsuaki, MD, Tsuyoshi Itoh, MD,

Minimally invasive direct coronary artery bypass in a cardiac transplant recipient with allograft vasculopathy Ivan Aleksic, MD, PhD, Jarowit A Piotrowski,

An experimental model of chronic myocardial hibernation

Sérgio A de Oliveira, MD The Annals of Thoracic Surgery

Stunned myocardium after off-pump coronary artery bypass grafting

Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Reappraisal of coronary endarterectomy for the treatment of diffuse coronary artery disease Thoralf M Sundt, MD, Cynthia J Camillo, RN, Eric N Mendeloff,

OPCAB for Acute LAD Dissection Due to Blunt Chest Trauma

Presentation transcript:

Therapeutic angiogenesis induced by local autologous bone marrow cell implantation Kimikazu Hamano, MD, Tao-Sheng Li, MD, Toshiro Kobayashi, MD, Ken Hirata, MD, Masafumi Yano, MD, Michihiro Kohno, MD, Masunori Matsuzaki, MD The Annals of Thoracic Surgery Volume 73, Issue 4, Pages 1210-1215 (April 2002) DOI: 10.1016/S0003-4975(02)03373-8

Fig 1 Experimental canine chronic coronary occlusion model (A) and the schedule of treatments (B). The canine chronic coronary occlusion model was made by ligating the left anterior descending artery (LAD) and all the diagonal branches and distal sites of the oblique marginal branches. Shown are (a) the attached positions of a single crystal in the normal area, (b) the marginal area, and (c) the infarction area. Black dots indicate the injection sites of bone marrow implantation. (Cx = circumflex artery; BMCs = bone marrow cells; PBS = phosphate-buffered saline; %WT = percent wall thickening; Echo = echocardiography.) The Annals of Thoracic Surgery 2002 73, 1210-1215DOI: (10.1016/S0003-4975(02)03373-8)

Fig 2 Changes in local cardiac wall motion in the normal area (left), the marginal area (middle), and the infarction area (right) after bone marrow cell implantation. Representative recording of wall thickening measured by ultrasonic transducer (upper and middle panel). The percent wall thickening (lower panel) was calculated by systolic thickening divided by end-diastolic thickness. In the marginal area, the percent wall thickening was significantly greater in the BMCI group than in the PBS group. (BMCI = bone marrow cell implantation group; PBS = phosphate-buffered saline injection group; Pre = before injection; Post = 30 days after injection, %WT = percent wall thickening.) The Annals of Thoracic Surgery 2002 73, 1210-1215DOI: (10.1016/S0003-4975(02)03373-8)

Fig 3 Immunohistochemical staining with canine anti-CD34 in (A) the phosphate-buffered saline injection (PBS) group and (B) the bone marrow cell implantation (BMCI) group in the marginal area. (C) Quantitative analysis of the microvessel density in each area showed that the density of microvessels in the marginal area was significantly higher in the BMCI group than in the PBS group. The Annals of Thoracic Surgery 2002 73, 1210-1215DOI: (10.1016/S0003-4975(02)03373-8)