Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with.

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Presentation transcript:

Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum Daniel Escorsim Machado, M.Sc., Maurício Simões Abrao, M.D., Ph.D., Plínio Tostes Berardo, M.D., Ph.D., Christina Maeda Takiya, M.D., Ph.D., Luiz Eurico Nasciutti, Ph.D. Fertility and Sterility Volume 90, Issue 1, Pages 148-155 (July 2008) DOI: 10.1016/j.fertnstert.2007.05.076 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Von Willebrand Factor staining of vessels in proliferative endometrium (A), secretory endometrium (B), normal ovary (C), normal bladder (D), normal rectum (E), ovarian endometriosis (F), bladder endometriosis (G), and rectal endometriosis (H). The distribution of the von Willebrand Factor–positive vessels was localized throughout the stroma and concentrated around the glands (arrows). Note a significant augmentation of the number of blood vessels in rectal endometriosis. Magnification ×400. Fertility and Sterility 2008 90, 148-155DOI: (10.1016/j.fertnstert.2007.05.076) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Proliferative endometrium (A), secretory endometrium (B), ovarian endometriosis (C), bladder endometriosis (D), and rectal endometriosis (E) immunostained with an antibody against vascular endothelial growth factor (VEGF). The glandular epithelium of the eutopic endometrium in both phases and of the bladder and rectal endometriosis exhibits positive VEGF immunostaining (arrows); in ovarian endometriosis the distribution of the immunoperoxidase product is observed in endometrial stroma (arrow). The immunoreaction is higher in cases of endometriosis compared with proliferative and secretory endometrium, especially in rectal endometriosis. Note also some blood vessel immumunoreactivity in the stromal tissues (arrowheads). Magnification ×400. Fertility and Sterility 2008 90, 148-155DOI: (10.1016/j.fertnstert.2007.05.076) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Immunohistochemical staining with vascular endothelial growth factor (VEGF) receptor Flk-1 antibody in proliferative endometrium (A), secretory endometrium (B), ovarian endometriosis (C), bladder endometriosis (D), and rectal endometriosis (E). The pattern of distribution of the Flk-1 staining is very similar as with the VEGF study, with anti–Flk-1 antibody immunoreactivity in glandular epithelium of the proliferative and secretory endometrium and of the bladder and rectal endometriosis (arrows); the endometrial stroma in the ovarian endometriosis also exhibits positive Flk-1 immunostaining (arrow). The concentration of the immunostaining with Flk-1 is more abundant in cases of endometriosis compared with the eutopic endometrium in both phases and again higher in rectal endometriosis, as in the VEGF study. Magnification ×400. Fertility and Sterility 2008 90, 148-155DOI: (10.1016/j.fertnstert.2007.05.076) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions