Biodegradable polymer coating promotes the epithelization of tissue-engineered airway prostheses Toshihiko Sato, MD, Masato Araki, MD, Naoki Nakajima,

Slides:

Advertisements

Similar presentations

Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji.

Advertisements

In vitro tissue engineering of a cardiac graft using a degradable scaffold with an extracellular matrix–like topography Osamu Ishii, MD, Michael Shin,

Manuel J. Antunes, MD, PhD, DSc

Biodegradable polymer with collagen microsponge serves as a new bioengineered cardiovascular prosthesis Shigemitsu Iwai, MD, Yoshiki Sawa, MD, Hajime.

Tracheal regeneration: Myth or fact?

Incomplete transmural ablation caused by bipolar radiofrequency ablation devices Wataru Kato, MD, Akihiko Usui, MD, Hideki Oshima, MD, Toshiaki Akita,

Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential Lorenzo Boni, MD,

In situ tissue engineering for tracheal reconstruction using a luminar remodeling type of artificial trachea Tatsuo Nakamura, MD, Toshihiko Sato, Masato.

Prevention of the second stage of epithelial loss is a potential novel treatment for bronchiolitis obliterans Yunge Zhao, MD, PhD, John F. Steidle, BA,

Development of new biodegradable hydrogel glue for preventing alveolar air leakage Masato Araki, MD, Hiroyuki Tao, MD, PhD, Naoki Nakajima, PhD, Hajime.

Vascular anastomoses with laser energy

Tracheal regeneration: Evidence of bone marrow mesenchymal stem cell involvement Agathe Seguin, MD, PhD, Sonia Baccari, MD, Muriel Holder-Espinasse, MD,

Tracheal cartilage regeneration by slow release of basic fibroblast growth factor from a gelatin sponge Hitoshi Igai, MD, Yasumichi Yamamoto, MD, Sung.

Creation of a uniform pleural defect model for the study of lung sealants Masato Araki, MD, Hiroyuki Tao, MD, PhD, Toshihiko Sato, MD, Naoki Nakajima,

Novel Tissue-Engineered Biodegradable Material for Reconstruction of Vascular Wall Shigemitsu Iwai, MD, Yoshiki Sawa, MD, Satoshi Taketani, MD, Kei Torikai,

Preliminary experience with tissue engineering of a venous vascular patch by using bone marrow–derived cells and a hybrid biodegradable polymer scaffold

Morphologic Assessment of Extracellular Matrix Scaffolds for Patch Tracheoplasty in a Canine Model Thomas W. Gilbert, PhD, Sebastien Gilbert, MD, Matthew.

The trachea: The first tissue-engineered organ?

Asthma therapy and airway remodeling

Fernando Villegas-Álvarez, MD, José F

The days of future past Neel K. Ranganath, MD, Aubrey C. Galloway, MD

Stem cells and bronchial stump healing

Cellular coating of the left ventricular assist device textured polyurethane membrane reduces adhesion of Staphylococcus aureus Tomohiro Asai, MD, Mei-Ho.

Electromechanical characterization of a tissue-engineered myocardial patch derived from extracellular matrix Takeyoshi Ota, MD, PhD, Thomas W. Gilbert,

Compound polyglactin 910/polypropylene small vessel prostheses

New tubular bioabsorbable knitted airway stent: Biocompatibility and mechanical strength Yukihito Saito, MDa, Kenichirou Minami, MDa, Masashi Kobayashi,

Intrinsic cardiac stem cells are essential for regeneration

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

First human transplantation of a bioengineered airway tissue

Midterm clinical result of tissue-engineered vascular autografts seeded with autologous bone marrow cells Toshiharu Shin’oka, MD, PhD, Goki Matsumura,

Histologic findings after explantation of a modified expanded polytetrafluoroethylene graft used for clinical systemic-to-pulmonary shunting Koji Takeda,

Large cell carcinoma arising in bronchogenic cyst

Experimental study of a new sutureless intraluminal graft with a shape-memory alloy ring Chuanrui Yang, MD, Yanqing Sun, MD, Peiqing Dong, MD, Huazhong.

Teratoma with malignant transformation in the anterior mediastinum

Hiromichi Miwa, MD, Takehisa Matsuda, PhD Journal of Vascular Surgery

The lord of the rings Antonio Miceli, MD, PhD

Nervin Fanous, MD, S. Adil Husain, MD, Mark Ruzmetov, MD, PhD, Mark D

A self-renewing, tissue-engineered vascular graft for arterial reconstruction Kei Torikai, MD, Hajime Ichikawa, MD, PhD, Koichiro Hirakawa, MS, Goro Matsumiya,

Closure of the Pericardium Using Synthetic Bioabsorbable Polymers

In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding Takenori Yokota, MD, Hajime Ichikawa,

Successful allotransplantation of cryopreserved tracheal grafts with preservation of the pars membranacea in nonhuman primates Tomohiro Murakawa, MD,

Dacron inhibition of arterial regenerative activities

The tissue-engineered vascular graft using bone marrow without culture

Tracheal allotransplantation in beagle dogs without immunosuppressants

Intrathoracic tracheal reconstruction with a collagen-conjugated prosthesis: Evaluation of the efficacy of omental wrapping Masayoshi Teramachi, MDa,

It's not “just a shunt” but sometimes it should be…

Implanted pedicled autologous pericardium mimics vasculature tissue: Case report Naoki Masaki, MD, Osamu Adachi, MD, PhD, Shunsuke Kawamoto, MD, PhD,

Do we need a bibliometrician to know which way the wind is blowing?

A first start for lung transplantation?

Carinal reconstruction with a Y-shaped collagen-conjugated prosthesis

Three-layered synthetic pericardial substitutes reduce postoperative pericardial adhesions Noriyoshi Kajihara, MD, Masataka Eto, MD, Yasuhisa Oishi,

The Ross procedure: Time to reevaluate the guidelines

Histological confirmation of healing of gastrobronchial fistula using a muscle flap Manabu Okuyama, MD, Reijiro Saito, MD, Satoru Motoyama, MD, Michihiko.

Polyurethane vascular prostheses decreases neointimal formation compared with expanded polytetrafluoroethylene Marc G. Jeschke, MD, Valentin Hermanutz,

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Prognosis and “granularity”: Building on staging foundations?

Recurrent catamenial hemopneumothorax treated by coverage with polyglycolic acid sheets Mamoru Takahashi, MD, Tadashi Matsukura, MD, PhD, Takashi Hirai,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

Hope should not spring eternal

External tracheal stenting for pediatric airway obstruction: A word of caution Roosevelt Bryant, MD The Journal of Thoracic and Cardiovascular Surgery

Replacement of a tracheal defect with a tissue-engineered prosthesis: Early results from animal experiments Jhingook Kim, MD, Soo Won Suh, PhD, Ji Yeon.

“The more things change…”: The challenges ahead

Lung cancer randomized controlled trials should compare stereotactic body radiation therapy with observation, NOT surgery Raja M. Flores, MD The Journal.

Bronchoscopic treatment of postpneumonectomy bronchopleural fistula with a collagen screw plug Hiroyuki Tao, MD, Masato Araki, MD, Toshihiko Sato, MD,

Did you like Terminator 3 better than Terminator 2

Lessons learned from Melody valve retrieved at transplantation

Experimental study on a new tracheal prosthesis made from collagen-conjugated mesh Norihito Okumura, MD, Tatsuo Nakamura, MD, Tohru Natsume, MD, Kenji.

Presentation transcript:

Biodegradable polymer coating promotes the epithelization of tissue-engineered airway prostheses Toshihiko Sato, MD, Masato Araki, MD, Naoki Nakajima, PhD, Koichi Omori, MD, Tatsuo Nakamura, MD The Journal of Thoracic and Cardiovascular Surgery Volume 139, Issue 1, Pages 26-31 (January 2010) DOI: 10.1016/j.jtcvs.2009.04.006 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, The bulk structure of the prosthesis framework: a mesh cylinder reinforced with 5 rings of polypropylene string. B, Cross-sectional schema of the prosthesis conjugated with a collagen layer. The L-lactic acid-co-ε-caprolactam (L–C copolymer) layer is colored blue. The Journal of Thoracic and Cardiovascular Surgery 2010 139, 26-31DOI: (10.1016/j.jtcvs.2009.04.006) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Periodical bronchoscopic views of the replaced portion after tracheal replacement. At day 0, the replaced portion can be identified by the blue-colored copolymer layer. At day 7, the copolymer coating remained. At day 14, regenerated reddish tissue could be observed, and the copolymer coating had apparently disappeared. At day 21, the luminal surface was covered with whitish tissue. At day 30, the luminal surface was completely covered with a smooth epithelium. At day 180, neomucosae with regenerated blood vessels were observed (arrows). The Journal of Thoracic and Cardiovascular Surgery 2010 139, 26-31DOI: (10.1016/j.jtcvs.2009.04.006) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A, Macroscopic view of the luminal surface of the prosthesis 18 months after implantation. The arrow shows the regenerated part. The luminal surface is covered with apparently normal mucosa. B, Microscopic examination of a longitudinal section of the regenerated tissue 18 months after prosthesis implantation. The regenerated neomucosa with an epithelial lining is observed on the prosthesis. (Hematoxylin and eosin staining, magnification 10×.) C, Ciliated columnar epithelial cells have grown over the prosthesis, whereas the center of the prosthesis is not as dense as in the peripheral regions. (Hematoxylin and eosin staining, magnification 40×.) L, Bronchial lumen; P, polypropylene mesh. The Journal of Thoracic and Cardiovascular Surgery 2010 139, 26-31DOI: (10.1016/j.jtcvs.2009.04.006) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions