Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort Anna.

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Presentation transcript:

Prediction of peanut allergy in adolescence by early childhood storage protein-specific IgE signatures: The BAMSE population-based birth cohort Anna Asarnoj, MD, PhD, Carl Hamsten, PhD, Christian Lupinek, MD, PhD, Erik Melén, MD, PhD, Niklas Andersson, MSc, Josep M. Anto, MD, PhD, Jean Bousquet, MD, PhD, Rudolf Valenta, MD, Marianne van Hage, MD, PhD, Magnus Wickman, MD, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 2, Pages 587-590.e7 (August 2017) DOI: 10.1016/j.jaci.2016.12.973 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Evolution of sensitization (IgE ≥ 0.3 ISU-E or ≥0.35 kU/L, respectively) prevalence (A) and IgE levels among sensitized individuals (B) to peanut allergen molecules and peanut extract at age 4, 8, and 16 years in a population-based study group (N = 778). ¤Proportion permanently desensitized if once sensitized to the specific allergen molecule (remission). For comparison with Ara h 8 sensitization, sensitization rates to birch Bet v 1 were 12.6%, 17.5%, and 25.8% at age 4, 8, and 16 years, respectively. IgE levels to peanut allergen molecules and peanut extract did not differ significantly among sensitized individuals in the population-based study group (n = 778) compared with the additional peanut extract–sensitized participants (n = 84). Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Peanut and birch pollen extract sensitization overlap measured with ImmunoCAP (≥0.35 kUA/L) at age 4, 8, and 16 years. Proportion of Ara h 2 sensitization and Ara h 8 monosensitization in the subgroups measured with the MeDALL chip (≥0.3 ISU-E). N = 778 (population-based study group). P values from t test on log-transformed values, not including the 0 values in each symptom subgroup. Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Venn diagram showing the study population of 862 participants (indicated in dark blue) derived from the BAMSE cohort (N = 4089): A subgroup of population-based participants (N = 778) enriched with peanut extract–sensitized participants (N = 84) from the group of eligible participants (N = 1699). Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Ara h 2/Ara h 6 sensitization overlap at age 4, 8, and 16 years. Median IgE levels (ISU-E) in the sensitization subgroups. N = 862 (peanut-enriched study group). Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Ara h 1/Ara h 2/Ara h 3 sensitization overlap at age 4, 8, and 16 years. Median IgE levels (ISU-E) in the sensitization subgroups. N = 862 (peanut-enriched study group). Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Likelihood of reporting symptoms to peanut at age 16 years in relation to (A) Ara h 2 IgE level at age 4 years (ISU-E), (B) Ara h 2 IgE level at age 4 years (ISU-E) (incident symptoms), (C) peanut extract IgE level at age 4 years (kUA/L), or (D) number of sensitizing peanut allergen molecules (Ara h 8 excluded)/peanut extract sensitization at age 4 years. N = 862 (peanut-enriched study group). Journal of Allergy and Clinical Immunology 2017 140, 587-590.e7DOI: (10.1016/j.jaci.2016.12.973) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions