Single–tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts Mike Kulis, PhD, Yifan Li, BS, Hannah.

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Presentation transcript:

Single–tree nut immunotherapy attenuates allergic reactions in mice with hypersensitivity to multiple tree nuts Mike Kulis, PhD, Yifan Li, BS, Hannah Lane, BS, Laurent Pons, PhD, Wesley Burks, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 81-88 (January 2011) DOI: 10.1016/j.jaci.2010.09.014 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cross-reactive IgE and IgG1 in the serum of mice after sensitization with cashew proteins. A, Food-specific IgE demonstrating cross-reactivity are shown as averages with standard deviation. Significant differences (∗P < .05; ∗∗P < .01) between specified foods; lines above bars indicate significant difference from all foods under the line. B, Left panel, Coomassie blue–stained SDS-PAGE gel. Right panel, Western blot showing proteins recognized by IgG1. Red box (…) indicates vicilin proteins; cyan box indicates legumin proteins; black box (---) indicates 2S albumin proteins. CSH, Cashew; MW, molecular weight standards; PN, peanut; PST, pistachio; WN, walnut. Journal of Allergy and Clinical Immunology 2011 127, 81-88DOI: (10.1016/j.jaci.2010.09.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Food challenges to assess efficacy of cashew immunotherapy (CSH-IT) in cross-reactivity mouse model. A, Cashew-sensitized mice treated with placebo or CSH-IT underwent a cashew challenge. Body temperatures and MMCP-1 levels are shown as averages with SDs. Symptoms are shown for individual mice. B, Results from the pistachio challenge. Significant differences (∗P < .05; ∗∗P < .01). Journal of Allergy and Clinical Immunology 2011 127, 81-88DOI: (10.1016/j.jaci.2010.09.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Food challenges to assess efficacy of immunotherapy in a multisensitization mouse model. A, Mice having undergone immunotherapy (treatment [Tx] groups shown on x-axis) were challenged with cashew (CSH). Body temperatures (45 minutes) and MMCP-1 levels are shown as averages with SDs. Symptoms are shown for individual mice. B, Mice having undergone immunotherapy were challenged with walnut (WN). ∗∗ or #, Significant differences (P < .01) between indicated group and placebo; Δ indicates significant differences (P < .05) between indicated group and placebo. Journal of Allergy and Clinical Immunology 2011 127, 81-88DOI: (10.1016/j.jaci.2010.09.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Specific IgG1 levels after immunotherapy (IT) are shown as averages with SDs. A, Cross-reactivity model: cashew-specific IgG1 levels for placebo and cashew immunotherapy (CSH-IT) groups. B, Multisensitization model: cashew-specific and walnut-specific IgG1 levels for placebo, walnut plus cashew immunotherapy (WN+CSH), cashew immunotherapy (CSH), and walnut immunotherapy (WN). Significant differences (∗P < .05 or ∗∗P < .01). Journal of Allergy and Clinical Immunology 2011 127, 81-88DOI: (10.1016/j.jaci.2010.09.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Cytokines secreted from splenocytes after immunotherapy. IL-4 (A), IL-5 (B), and IL-12 (C) were measured after 96 hours of stimulation with the indicated antigen; RPMI, medium alone. CSH/PBS or CSH/CSH-IT, cashew-sensitized mice treated with placebo or cashew immunotherapy, respectively; Egg/PBS or Egg/CSH-IT, egg-sensitized mice treated with placebo or cashew immunotherapy, respectively. ∗Significant differences (P < .05). Journal of Allergy and Clinical Immunology 2011 127, 81-88DOI: (10.1016/j.jaci.2010.09.014) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions