Detection of Activated, TIMP-free MMPs

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Presentation transcript:

Detection of Activated, TIMP-free MMPs Stanley Zucker, Jian Cao Chemistry & Biology Volume 13, Issue 4, Pages 347-349 (April 2006) DOI: 10.1016/j.chembiol.2006.04.002 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Cartoon Describing the Competition between Exogenous MMP Inhibitor-Tethered Resin Binding and Endogenous TIMP Binding of Activated MMP-2 in the Extracellular Space Following propeptide cleavage, the catalytic site of MMP-2 is exposed and capable of binding to inhibitors. For simplicity, the triplex formed on the cell surface consisting of MT1-MMP, TIMP-2, and proMMP-2 leading to generation of activated MMP-2 is omitted. Chemistry & Biology 2006 13, 347-349DOI: (10.1016/j.chembiol.2006.04.002) Copyright © 2006 Elsevier Ltd Terms and Conditions