Cytomegalovirus Infection Agnes Fogo, MD  American Journal of Kidney Diseases  Volume 36, Issue 2, Pages E7-E8 (August 2000) DOI: 10.1053/S0272-6386(13)90031-7 Copyright © 2000 National Kidney Foundation, Inc. Terms and Conditions

Fig 1 Cytomegalovirus infection is diagnosed by the appearance of large cells with basophilic enlarged nuclei with inclusions. There is frequent tubular injury and degeneration. Cytomegalovirus infection most commonly affects tubular epithelial cells and occurs most commonly in the transplant. (Hematoxylin and eosin, original magnification ×100). American Journal of Kidney Diseases 2000 36, E7-E8DOI: (10.1053/S0272-6386(13)90031-7) Copyright © 2000 National Kidney Foundation, Inc. Terms and Conditions

Fig 2 The marked enlargement of the tubular epithelial cells with markedly enlarged nuclei and degeneration is evident in this case of cytomegalovirus infection in the transplant. (Hematoxylin and eosin, original magnification ×1,000). American Journal of Kidney Diseases 2000 36, E7-E8DOI: (10.1053/S0272-6386(13)90031-7) Copyright © 2000 National Kidney Foundation, Inc. Terms and Conditions

Fig 3 Cytomegalovirus infection may also rarely involve the glomerulus, as in this transplant patient where there is marked enlargement of visceral epithelial cells with enlarged nuclei and owls'eye type nuclear inclusions (left). (Hematoxylin and eosin, original magnification ×400). American Journal of Kidney Diseases 2000 36, E7-E8DOI: (10.1053/S0272-6386(13)90031-7) Copyright © 2000 National Kidney Foundation, Inc. Terms and Conditions

Fig 4 Cytomegalovirus can also be seen by electron microscopy. The virus has a typical bull's eye appearance when present in the cytoplasm, where it has picked up an extra layer of the nuclear membrane. (Transmission electron microscopy, original magnification ×200,000). American Journal of Kidney Diseases 2000 36, E7-E8DOI: (10.1053/S0272-6386(13)90031-7) Copyright © 2000 National Kidney Foundation, Inc. Terms and Conditions