PAF Makes It EZ(H2) for β-Catenin Transactivation

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PAF Makes It EZ(H2) for β-Catenin Transactivation Xinjun Zhang, Xi He Molecular Cell Volume 52, Issue 2, Pages 157-158 (October 2013) DOI: 10.1016/j.molcel.2013.10.008 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 β-Catenin Transactivation Mediated by PAF and EZH2 in the G1 Phase and a Speculative Role of β-Catenin in Modulating PAF-PCNA-Dependent DNA Replication and Repair/Bypass Pathways in the S Phase In G1, PAF and EZH2 hyperactivate β-catenin-dependent transcription via association with β-catenin and recruitment of mediator (MED) and RNA polymerase II (Pol II) complexes (left). In S, β-catenin may compete with PCNA for binding to PAF and thus modulate PAF-PCNA-dependent DNA replication and repair/bypass (right). The dashed outline boxes the speculation. Molecular Cell 2013 52, 157-158DOI: (10.1016/j.molcel.2013.10.008) Copyright © 2013 Elsevier Inc. Terms and Conditions