Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time- dependent manner: proposed model-specific scoring systems M. Udo, T.

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Presentation transcript:

Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time- dependent manner: proposed model-specific scoring systems M. Udo, T. Muneta, K. Tsuji, N. Ozeki, Y. Nakagawa, T. Ohara, R. Saito, K. Yanagisawa, H. Koga, I. Sekiya Osteoarthritis and Cartilage Volume 24, Issue 7, Pages 1284-1291 (July 2016) DOI: 10.1016/j.joca.2016.02.005 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Study schema. Rats had a single monoiodoacetic acid (MIA) injection in the right knee and phosphate buffer saline (PBS) in the left knee. The knees were evaluated at 2, 4, 6, 8 and 12 weeks after injection. For the control, the left knee of rats which had a 0.1 mg injection in the right knee, was used. Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Representative macroscopic features of the femoral and tibial condyle cartilage. (A) Images without India ink staining. Macroscopic cartilage score introduced in Table I is shown in each image. The tibial image with median value is selected among four samples and the femur is selected from the same knee. In the control group, the images of the left knee were inverted horizontally to match the images in the other groups. (B) Images with India ink staining. Punctate depressions are indicated with white arrowheads. Erosions are surrounded with yellow arrowheads. Areas of bone destruction are surrounded with red arrowheads. A; anterior, P; posterior, M; medial, L; lateral. Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 Macroscopic cartilage score for femoral condyle and tibial plateau. Values are means with 95% confidence interval (n = 4). Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 4 Histological analyses for the tibial condyle. (A) Representative histological features of the tibial condyle. Medial tibial condyle was sectioned in the sagittal plane and stained with safranin-o. OARSI histological score and Mankin score are shown in each image. The tibial plateau image with median value is demonstrated. A; anterior, P; posterior, O; OARSI histological score, M; Mankin score. (B) OARSI histological score for tibial cartilage. Values are means with 95% confidence interval (n = 4). (C) Mankin score for tibial cartilage. Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 5 Analysis for infrapatellar fat pad (IFP). (A) Study schema. (B) Representative histological images for the IFP. Whole knee joints were sectioned in the sagittal plane stained with hematoxylin and eosin. Infrapatellar fat pad inflammation score (surface score + body score) are shown in each image. (C) Infrapatellar fat pad inflammation score. Values are means with 95% confidence interval (n = 4). Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions

Supplementary Fig. 1 Representative histological features of the tibial plateau. Medial tibial plateau was sectioned in the sagittal plane and immunostained with type II collagen. Osteoarthritis and Cartilage 2016 24, 1284-1291DOI: (10.1016/j.joca.2016.02.005) Copyright © 2016 The Authors Terms and Conditions