Patricia Goldman-Rakic

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Presentation transcript:

Patricia Goldman-Rakic Amy F.T Arnsten  Neuron  Volume 40, Issue 3, Pages 465-470 (October 2003) DOI: 10.1016/S0896-6273(03)00685-8

Figure 1 Patricia Goldman-Rakic Neuron 2003 40, 465-470DOI: (10.1016/S0896-6273(03)00685-8)

Figure 2 The Photograph of Columnar Inputs to the Principal Sulcal Prefrontal Cortex Pat Goldman and Walle Nauta injected tritiated amino acids into the contralateral principal sulcus and traced the anterograde connections to cortical and subcortical structures. This photo hung in her office from then on. Neuron 2003 40, 465-470DOI: (10.1016/S0896-6273(03)00685-8)

Figure 3 A Version of the Humorous Slide Pat Would Show in the Early 1980s, Schematically Depicting the Paucity of Scientists Researching Prefrontal Cortex Neuron 2003 40, 465-470DOI: (10.1016/S0896-6273(03)00685-8)

Figure 4 An Artistic Depiction of the Sensory Inputs to Prefrontal Cortex, as Interpretted by Pat's Former Graduate Student, S. Mark Williams, Duke University Neuron 2003 40, 465-470DOI: (10.1016/S0896-6273(03)00685-8)

Figure 5 A Representative Memory Field of a Neuron in the Prefrontal Cortex of a Monkey Performing the Oculomotor Delayed Response Task, and the Circuitry which Pat Thought Created This Response Profile (A) The memory field of a prefrontal cortical neuron that responds best to stimuli that had been flashed at the 270° position and is inhibited when stimuli had been in the 90° position. The task is schematically represented in the center of the figure; the monkey would view a cue at one of the eight spatial positions and then remember this information over a delay period of several seconds. FP signifies fixation point. (B) The neural circuitry that may underlie delay-related activity. Excitatory pyramidal cells are represented by triangles; inhibitory interneurons by circles. Adapted from Goldman-Rakic, 1995. Neuron 2003 40, 465-470DOI: (10.1016/S0896-6273(03)00685-8)