Genomic risk of hepatitis C-related hepatocellular carcinoma Yujin Hoshida, Bryan C. Fuchs, Kenneth K. Tanabe  Journal of Hepatology  Volume 56, Issue 3, Pages 729-730 (March 2012) DOI: 10.1016/j.jhep.2011.08.015 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Progression of chronic hepatitis C. After the establishment of chronic infection of hepatitis C virus, a subset of patients progresses into the next disease state assumedly through the interaction of host genetic, viral, and/or environmental risk factors. Risk allele A at rs2596542 is not associated with susceptibility to hepatitis C infection but is associated with occurrence of HCC. It remains to be determined exactly how risk allele A increases the risk of HCC development; for example by inducing chronic active hepatitis, cirrhosis progression, or tumor formation. Journal of Hepatology 2012 56, 729-730DOI: (10.1016/j.jhep.2011.08.015) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions