A Noncanonical Path to Mechanism of Action Randall T. Peterson  Chemistry & Biology  Volume 13, Issue 9, Pages 924-926 (September 2006) DOI: 10.1016/j.chembiol.2006.09.002 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Use of Zebrafish for Deciphering Small-Molecule Mechanisms of Action Treating zebrafish embryos with a small molecule often generates a distinctive phenotype. By comparing the phenotype with databases of existing zebrafish phenotypes, candidate targets for the small molecule can often be identified. As described in this issue, fumagillin causes a truncated tail phenotype similar to that caused by Wnt5 mutation and other perturbations of noncanonical Wnt signaling. Chemistry & Biology 2006 13, 924-926DOI: (10.1016/j.chembiol.2006.09.002) Copyright © 2006 Elsevier Ltd Terms and Conditions