SIP-ing the Elixir of Youth

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SIP-ing the Elixir of Youth William Mair, Kristan K. Steffen, Andrew Dillin Cell Volume 146, Issue 6, Pages 859-860 (September 2011) DOI: 10.1016/j.cell.2011.08.026 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 The Deactylation Life Span Clock Deacetylation of the yeast AMPK subunit Sip2 with time acts as an intrinsic aging clock, which drives cellular aging by a mechanism that is distinct from the effects of dietary restriction. As yeast cells age, Sip2 becomes deacetylated, removing its repression of the AMPK homolog Snf1 and inducing cellular aging via Sch9 phosphorylation. The life span clock can be wound backward via Sip2 acetylation mimics or by inactivating the deacetylase Rpd3, promoting longevity. These findings describe a novel level of AMPK regulation with age and pose new questions about the links between energy homeostasis and longevity and the potential of AMPK as a target to treat age-related disease. Cell 2011 146, 859-860DOI: (10.1016/j.cell.2011.08.026) Copyright © 2011 Elsevier Inc. Terms and Conditions