ERCC1 and BRAC1 mRNA Expression Levels in the Primary Tumor Could Predict the Effectiveness of the Second-Line Cisplatin-Based Chemotherapy in Pretreated.

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ERCC1 and BRAC1 mRNA Expression Levels in the Primary Tumor Could Predict the Effectiveness of the Second-Line Cisplatin-Based Chemotherapy in Pretreated Patients with Metastatic Non-small Cell Lung Cancer Chara Papadaki, BSc, PhD, Maria Sfakianaki, MSc, Georgios Ioannidis, MD, Eleni Lagoudaki, MD, Maria Trypaki, BSc, Kostas Tryfonidis, MD, Dimitris Mavroudis, MD, PhD, Efstathios Stathopoulos, MD, PhD, Vassilis Georgoulias, MD, PhD, John Souglakos, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 4, Pages 663-671 (April 2012) DOI: 10.1097/JTO.0b013e318244bdd4 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Flow chart of the study. Journal of Thoracic Oncology 2012 7, 663-671DOI: (10.1097/JTO.0b013e318244bdd4) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Progression-free survival (PFS) according to BRCA1 (A), ERCC1 (B), and BRCA1–ERCC1 combined (Cc mRNA expression levels. Lower levels of BRCA1 (A), ERCC1 (B), and both genes (C) were associated with significantly decreased PFS (for more details see Table 2). Journal of Thoracic Oncology 2012 7, 663-671DOI: (10.1097/JTO.0b013e318244bdd4) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Median overall survival (OS) according to BRCA1 (A), ERCC1 (B), and BRCA1–ERCC1 combined expression (C) mRNA expression levels. Lower levels of BRCA1 (A), ERCC1 (B), and both genes (C) were associated with significantly decreased progression-free survival (for more details see Table 2). Journal of Thoracic Oncology 2012 7, 663-671DOI: (10.1097/JTO.0b013e318244bdd4) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions