B. Kaleem, F. Maier, H. Drissi, D.M. Pierce

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Presentation transcript:

Low-energy impact of human cartilage: predictors for microcracking the network of collagen B. Kaleem, F. Maier, H. Drissi, D.M. Pierce Osteoarthritis and Cartilage Volume 25, Issue 4, Pages 544-553 (April 2017) DOI: 10.1016/j.joca.2016.11.009 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative test data from Donor 1 vs. time: (a) measured acceleration (solid blue) and force (dashed red), (b) calculated velocity, and (c) calculated displacement. Characteristic sections used for data analysis: (I) indentor free fall, (II) compression, and (III) rebound. Osteoarthritis and Cartilage 2017 25, 544-553DOI: (10.1016/j.joca.2016.11.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean and 95% CI (n = 18) for predictors (calculated test parameters): (a) impact energy density, (b) energy dissipation density, (c) nominal stress, (d) nominal stress rate, (e) strain, and (f) strain rate for all test conditions. Osteoarthritis and Cartilage 2017 25, 544-553DOI: (10.1016/j.joca.2016.11.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative SHG images taken parallel to and ∼30 μm from the articular surface within impacted specimens and the corresponding image analyses of microcracks: (a), (b) original SHG images from two-photon microscope (red boxes indicate areas for subsequent analyses); (c), (d) processed binary images; and (e), (f) resulting distance maps after removal of lacunae and other non-microcrack features. Left column ((a), (c), (e)): specimen from Donor 3 after impact with 0.05 J, 0.75 m/s; right column ((b), (d), (f)): specimen from Donor 5 after impact with 0.09 J, 1.0 m/s. Osteoarthritis and Cartilage 2017 25, 544-553DOI: (10.1016/j.joca.2016.11.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Outcomes for all 108 impact tests conducted under all test conditions where specimens presenting microcracks (any presence of microfractures within the network of collagen) are shown in dark red/blue and pristine specimens are shown in light red/blue. Osteoarthritis and Cartilage 2017 25, 544-553DOI: (10.1016/j.joca.2016.11.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Predicting the probability of microcracking in the network of collagen in human articular cartilage: binary logistic regression plots for (a) impact energy density, (b) energy dissipation density, (c) nominal stress, and (d) nominal stress rate. Osteoarthritis and Cartilage 2017 25, 544-553DOI: (10.1016/j.joca.2016.11.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions