The protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation Sadik Sahin, M.D.,

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The protective effects of tacrolimus on rat uteri exposed to ischemia-reperfusion injury: a biochemical and histopathologic evaluation Sadik Sahin, M.D., Ozlem Bingol Ozakpinar, Ph.D., Koray Ak, M.D., Mustafa Eroglu, M.D., Merve Acikel, M.Sc., Sermin Tetik, Ph.D., Fikriye Uras, Ph.D., Sule Cetinel, M.D. Fertility and Sterility Volume 101, Issue 4, Pages 1176-1182 (April 2014) DOI: 10.1016/j.fertnstert.2013.12.044 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The levels of malondialdehyde (MDA), glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) in the control, ischemia-reperfusion (I/R), and tacrolimus-treated groups. Each group consists of seven rats. Values are expressed as mean ± SD. ∗P<.0001, γP<.01 compared with control group. ∗∗P<.0001, ∗∗∗P<.001, ++P<.05 compared with I/R group. +P<.01, πP<.05 compared with pre-ischemia group. Fertility and Sterility 2014 101, 1176-1182DOI: (10.1016/j.fertnstert.2013.12.044) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Light microscopy findings of rat uterine tissue. (A) Control group; regular alignment of endometrial epithelium (arrow) and glandular cells (arrowheads), some polymorphonuclear cells in lamina propria (*). (B) Ischemia-reperfusion group: severe accumulation of polymorphonuclear cells in lamina propria (*), congestion of vessels, disruption of cells in glandular epithelium (inset, arrows). (C) Pre-ischemia tacrolimus: reduced density of polymorphonuclear cells in lamina propria, regeneration of glandular cell morphology (arrows). (D) Post-ischemia tacrolimus: regeneration of both endometrial (inset, arrow) and glandular (arrow) epithelium, note the reduced population of polymorphonuclear cells (*). Staining: hematoxylin-eosin. Fertility and Sterility 2014 101, 1176-1182DOI: (10.1016/j.fertnstert.2013.12.044) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Analysis of semithin sections of rat uterine tissue. (A) Control group: regular contour of glandular epithelium (arrowheads), lamina propria (*), and fibroblasts (f). (B) Ischemia-reperfusion group: severe edema in lamina propria (*), cytoplasmic edema and deterioration in glandular cells (arrowheads) with some pyknosis (arrows), fibroblastic degeneration (f) in lamina propria. (C) Pre-ischemia tacrolimus group: slight alteration in glandular cellular morphology (arrowheads), a pyknotic cell (arrow), mild disruption of lamina propria (*), fibroblast (f). (D) Post-ischemia tacrolimus group: reduced disruption in glandular cellular structures (arrowheads) with cytoplasmic edema, pyknotic cell (arrow), decreased edema, and reorganization of lamina propria (*). Staining: toluidine blue. Fertility and Sterility 2014 101, 1176-1182DOI: (10.1016/j.fertnstert.2013.12.044) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions