Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in.

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Differences in asthma genetics between Chinese and other populations

Pharmacologic rationale for treating allergic and nonallergic rhinitis

Fatty acids, inflammation, and asthma

Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation Hani Harb, MSc, Diana Raedler, PhD, Nikolaus Ballenberger,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese Ping-Ping Cao, MD, Hua-Bin Li, MD, PhD, Bao-Feng.

Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population Hui.

Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population Heung-Woo Park, MD, Jong-Eun.

Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Fatty acids, inflammation, and asthma

Differences in asthma genetics between Chinese and other populations

Allergy immunotherapy among Medicaid-enrolled children with allergic rhinitis: Patterns of care, resource use, and costs Cheryl S. Hankin, PhD, Linda.

Rising prevalence of asthma is sex-specific in a US farming population

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis George Philip, MD, Janet van Adelsberg, MD, Thomas Loeys, PhD, Nancy.

Physician needs in health informatics: Just ask the docs

A network-based analysis of the late-phase reaction of the skin

Peter M. Wolfgram, MD, David B. Allen, MD

Update on epigenetics in allergic disease

Etiology of asthma exacerbations

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis Anand Kumar Andiappan, PhD, Yang Yie Sio, BSc, Bernett.

Xingnan Li, PhD, Timothy D. Howard, PhD, Siqun L

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

What are the best outcome measurements for atopic eczema

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

News Beyond Our Pages Journal of Allergy and Clinical Immunology

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think Martin L. Moore, PhD, R.

What is an “eosinophilic phenotype” of asthma?

Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD

Michelle Daya, PhD, Kathleen C. Barnes, PhD

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

One step forward, 2 steps back: The enigma of preschool wheeze

A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis Peng Jin, BM, MSc, Anand.

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Reply Journal of Allergy and Clinical Immunology

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford,

The role of indoor allergens in chronic allergic disease

Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis Philippe-Jean Bousquet, MD, Christophe Combescure, PhD,

Acid-suppressive drug use in pregnancy and the toddler's asthma risk: A crossover, case-control study Bianca Mulder, BSc, Catharina Carolina Maria Schuiling-Veninga,

Measles and immunomodulation

The Editors' Choice Journal of Allergy and Clinical Immunology

Macrolide antibiotics and asthma treatment

A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations Lynette Pei-Chi Shek, MRCP,

Asthma: The past, future, environment, and costs

Genetic regulation of IgE responses: Achilles and the tortoise

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Environmental factors and eosinophilic esophagitis

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in Singapore Anand Kumar Andiappan, BTech, De Yun Wang, MD, PhD, Ramani Anantharaman, PhD, Bani Kaur Suri, MSc, Bernett Teck Kwong Lee, PhD, Olaf Rotzschke, PhD, Jianjun Liu, PhD, Fook Tim Chew, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 5, Pages 1431-1433.e8 (May 2013) DOI: 10.1016/j.jaci.2012.11.001 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Regulatory activity in the chromosome 11q13.5 locus containing the GWAS-reported SNPs rs2155219,E4 rs7130588,E5 and rs7927894.E6 From the UCSC genome browser, we could identify regulatory elements in this 35-kb locus with high reported enhancer activity, as shown by active histone marks, such as H3K27ac and H3K4me1, although not for H3KMe3, which marks for poised enhancer sites. The locus conserved in the mammalian genome also contains DNaseI hyperactivity clusters, which are crucial for transcription factor binding, which initiates and regulates gene expression. Journal of Allergy and Clinical Immunology 2013 131, 1431-1433.e8DOI: (10.1016/j.jaci.2012.11.001) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions