Multifunctional nanoparticles for improving function and multimodal tracking of mesenchymal stem cells for osteoarthritis treatment I.M. Adjei, H. Yang,

Slides:

Advertisements

Similar presentations

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Mesenchymal stromal cells for cartilage repair in osteoarthritis

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

In vitro cell surface markers are insufficient to identify in vivo/in situ multipotent synovial mesenchymal stem cells isolated from normal or osteoarthritic.

Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture Dr R.L. Mauck, Ph.D., X. Yuan, Dr.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Characterization of cartilage repair in a focal mouse defect model

The effects of dynamic viscosity on cartilage mechanics

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep C.C. Shu, A. Dart,

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Human synovial fluid derived mesenchymal stem cells expanded under low oxygen conditions and in a serum-free environment exhibit enhanced lineage-specific.

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

Mechanical response of articular cartilage damaged by macro cracks

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

The differences on extracellular matrix among each portion of meniscus

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

H. J. Nieminen, T. Ylitalo, S. Kauppinen, E. Hæggström, M. Finnilä, S

Osteoarthritis and Cartilage

Y. Zhou, L. Resutek, L. Wang, X. Lu Osteoarthritis and Cartilage

R. Nakamura, N. Komatsu, K. Fujita, H. Nishimura, Y. Katsuki

Stem cell therapy for human cartilage defects: a systematic review

N.D. Miljkovic, M.D., Ph.D., G.M. Cooper, Ph.D., K.G. Marra, Ph.D.

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Assessing the characteristics of human mesenchymal stromal cells derived from bone marrow and umbilical cord following expansion in the quantum® hollow-fibre.

Two different knee braces alter patella position: a moving image analysis using weight bearing magnetic resonance imaging M.J. Callaghan, N.D. Reeves,

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Cell surface receptor expression profile of human synovial mesenchymal stem cells in- vivo predicts their differentiation potential in-vitro N.U. Aljezani,

Measurement properties of the WOMAC LK 3.1 pain scale

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

G. Plumton, I. Adjei, A. Martin-Pena, G.D. Palmer, B. Sharma

Who should have a joint replacement? A plea for more ‘phronesis’

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Medial meniscus posterior horn zones show differing responses to static loading in subjects with knee osteoarthritis compared to controls N.E. Calixto,

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Development of growth factor tethered hyaluronan microspheres for in situ chondrogenic differentiation of human mesenchymal stem cells S. Ansboro, J.S.

F. Dell'Accio Osteoarthritis and Cartilage

A peptide temporally enhanced chondrogenesis of mesenchymal stem cells

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Novel juvenile factors for cartilage regeneration

K.D. Novakofski, R.M. Williams, L.J. Bonassar, L.A. Fortier

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Nanoparticle targeting to cartilage: effects of surface charge on nanoparticle interactions with joint tissues S.B. Brown, B. Sharma Osteoarthritis.

Osteoarthritis year 2012 in review: biology

S. Brown, J. Pistiner, B. Sharma Osteoarthritis and Cartilage

Optimal ratio of adipose stem cells and bone marrow stem cell to promote osteogenic differentiation and angiogenesis G.-I. Im, K.-I. Kim, N.-H. Jo Osteoarthritis.

Hip derived synovial mesenchymal progenitor cell surface markers as indicators for differentiation potential A. Affan, N. Al-Jezani, P. Railton, J. Powell,

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment G.-I. Im, J.-M. Lee, E.-A. Kim Osteoarthritis.

Biomechanical knee cartilage analysis in young professional soccer players by a T2 mapping unloading algorithm G.H. Welsch, L. Waldenmeier, C. Evers,

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Multifunctional nanoparticles for improving function and multimodal tracking of mesenchymal stem cells for osteoarthritis treatment I.M. Adjei, H. Yang, L. Maldonado-Camargo, J. Dobson, C. Rinaldi, H. Jiang, B. Sharma Osteoarthritis and Cartilage Volume 24, Pages S462-S463 (April 2016) DOI: 10.1016/j.joca.2016.01.843 Copyright © 2016 Terms and Conditions

Fig. l: Multipotency of magPLGA NPs loaded MSC Fig. l: Multipotency of magPLGA NPs loaded MSC. (A) Quantified oil red stain for adipogenesis and (B) image of adipocytes differentiated from magPLGA loaded MSCs. (C) Quantification of Alizarin red stain for osteogenesis of magPLGA loaded and unloaded NPs. (D) Image of Alizarin red stained osteocytes differentiated from magPLGA NP loaded cells. Osteoarthritis and Cartilage 2016 24, S462-S463DOI: (10.1016/j.joca.2016.01.843) Copyright © 2016 Terms and Conditions

Fig. 2: Photoacoustic imaging of magPLGA-loaded. MSCs Fig. 2: Photoacoustic imaging of magPLGA-loaded. MSCs. Alinear correlation exists between cell number and PA signal. R2 = 0.95. Osteoarthritis and Cartilage 2016 24, S462-S463DOI: (10.1016/j.joca.2016.01.843) Copyright © 2016 Terms and Conditions