Microarray Analysis of Thyroid Nodule Fine-Needle Aspirates Accurately Classifies Benign and Malignant Lesions Carrie C. Lubitz, Stacy K. Ugras, J. Jacob.

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Microarray Analysis of Thyroid Nodule Fine-Needle Aspirates Accurately Classifies Benign and Malignant Lesions Carrie C. Lubitz, Stacy K. Ugras, J. Jacob Kazam, Biaxin Zhu, Theresa Scognamiglio, Yao-Tseng Chen, Thomas J. Fahey The Journal of Molecular Diagnostics Volume 8, Issue 4, Pages 490-498 (September 2006) DOI: 10.2353/jmoldx.2006.060080 Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 Unsupervised hierarchical cluster analysis of individual hybridizations in the FNA test set using 25 differentially expressed genes (29 probe sets) established from the training set. Columns represent individual samples, rows represent genes, red indicates relative overexpression, and green indicates relative underexpression. FV, follicular variant of PTC. The Journal of Molecular Diagnostics 2006 8, 490-498DOI: (10.2353/jmoldx.2006.060080) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 Sections illustrating cytological heterogeneity within indeterminate tumors. Adjacent areas of lesion from patient FV3 (A, B) and patient FA3 (C, D). H&E stain. Original magnifications, ×40. The Journal of Molecular Diagnostics 2006 8, 490-498DOI: (10.2353/jmoldx.2006.060080) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 3 Unsupervised hierarchical cluster analysis of FNA samples and nine matched tissues (test set) using 25 differentially expressed genes (28 probe sets) established from the training set. Columns represent individual samples, rows represent genes, red indicates relative overexpression, and green indicates relative underexpression. The Journal of Molecular Diagnostics 2006 8, 490-498DOI: (10.2353/jmoldx.2006.060080) Copyright © 2006 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions