TFH-IgA Responses Keep Microbiota in Check

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TFH-IgA Responses Keep Microbiota in Check Kenya Honda Cell Host & Microbe Volume 17, Issue 2, Pages 144-146 (February 2015) DOI: 10.1016/j.chom.2015.01.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 TLR Ligands Derived from the Gut Microbiota Activate MyD88-Dependent Signaling in CD4+ T Cells Activated CD4+ T cells differentiate into TFH cells, which then instruct B cells to differentiate into high-affinity microbiota-specific IgA-expressing cells in Peyer’s patches. The secretory IgA produced by their plasma cell progeny in the lamina propria mainly binds to the bacteria located in the mucus layer close to the gut epithelium. This series of events is essential for keeping the entire microbiota symbiotic and diverse. Cell Host & Microbe 2015 17, 144-146DOI: (10.1016/j.chom.2015.01.009) Copyright © 2015 Elsevier Inc. Terms and Conditions