A Biomarker Harvest from One Thousand Cancer Cell Lines

Slides:



Advertisements
Similar presentations
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.
Advertisements

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.
Waging War on Cancer with the Sword of Immunity Cell Volume 158, Issue 2, (July 2014) DOI: /j.cell Copyright © 2014 Terms and Conditions.
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.
The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.
Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Treatment of Obesity with Celastrol
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.
Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm Jianbin Wang, H. Christina Fan, Barry Behr, Stephen.
UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.
Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.
Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies Hiroshi Haeno, Mithat Gonen, Meghan.
The Monarch Butterfly Genome Yields Insights into Long-Distance Migration Shuai Zhan, Christine Merlin, Jeffrey L. Boore, Steven M. Reppert Cell Volume.
Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell
ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair Julian Stingele, Michael S. Schwarz, Nicolas Bloemeke, Peter G. Wolf, Stefan Jentsch.
SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.
WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport Kenneth G. Campellone, Neil J. Webb, Elizabeth A. Znameroski,
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
SSB Functions as a Sliding Platform that Migrates on DNA via Reptation Ruobo Zhou, Alexander G. Kozlov, Rahul Roy, Jichuan Zhang, Sergey Korolev, Timothy.
Immunoengineering: How Nanotechnology Can Enhance Cancer Immunotherapy
Targeting Aneuploidy for Cancer Therapy
Volume 153, Issue 6, Pages (June 2013)
Accelerating drug discovery: Open source cancer cell biology?
Unweaving the Autism Spectrum
Driving Glioblastoma to Drink
Of Rats and Men Cell Volume 154, Issue 3, Pages (August 2013)
Communication in Drug Development: “Translating” Scientific Discovery
Cross-Species Oncogenomics in Cancer Gene Identification
Mapping Human Epigenomes
DAISY: Picking Synthetic Lethals from Cancer Genomes
Redefining Clinical Trials: The Age of Personalized Medicine
Volume 154, Issue 1, Pages (July 2013)
In This Issue Cell Volume 158, Issue 5, (August 2014)
Cancer Genomes Evolve by Pulverizing Single Chromosomes
It’s a SMAD/SMAD World Cell
Volume 152, Issue 1, (January 2013)
Volume 130, Issue 6, (September 2007)
When Biology Doesn’t Add Up
Volume 143, Issue 6, (December 2010)
Making the Most from Changes in Life
The Cell Biology of Genomes: Bringing the Double Helix to Life
The Plasticity of Aging: Insights from Long-Lived Mutants
Learning from the Uncontrollable
Volume 163, Issue 4, (November 2015)
Volume 163, Issue 2, (October 2015)
Chapter 78 Vaccination and Screening in Cervical Cancer
Volume 134, Issue 6, (September 2008)
David Hubel and Torsten Wiesel
Volume 12, Issue 6, Pages (December 2007)
Cellular Alchemy and the Golden Age of Reprogramming
In This Issue Cell Volume 145, Issue 3, (April 2011)
Volume 148, Issue 1, (January 2012)
Presentation transcript:

A Biomarker Harvest from One Thousand Cancer Cell Lines Yu-Han Huang, Christopher R. Vakoc  Cell  Volume 166, Issue 3, Pages 536-537 (July 2016) DOI: 10.1016/j.cell.2016.07.010 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Major Cancer Cell Line Drug Screening Initiatives The NCI-60 project was initiated in the 1980s and has to date tested >100,000 compounds in 59 cancer cell lines. More recently, the scale of cancer cell line drug screens has expanded dramatically (e.g., Cancer Cell Line Encyclopedia [CCLE]/Cancer Therapeutics Response Portal [CTRP], and Genomics of Drug Sensitivity in Cancer [GDSC]) and now includes a detailed genetic analysis of each cell line. Cell 2016 166, 536-537DOI: (10.1016/j.cell.2016.07.010) Copyright © 2016 Elsevier Inc. Terms and Conditions