Mitofilin is localized in individual clusters in the mitochondria of primary adult human fibroblasts. Mitofilin is localized in individual clusters in.

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Mitofilin is localized in individual clusters in the mitochondria of primary adult human fibroblasts. Mitofilin is localized in individual clusters in the mitochondria of primary adult human fibroblasts. (A) Cell overview. The mitochondrial network of a primary fibroblast is labeled with an antiserum against mitofilin (green). The microtubule cytoskeleton (red), the nucleus (blue) and the actin cytoskeleton (gray) are labeled as well. (B and C) STED super-resolution microscopy (C) reveals that mitofilin is localized in discrete clusters, which are blurred and not resolvable using diffraction-limited confocal microscopy (B) of the same region. (Insets) Magnification of the boxed areas. (Scale bars: 20 μm in A; 1 μm in B and C.)‏ Jans D C et al. PNAS 2013;110:8936-8941 ©2013 by National Academy of Sciences