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In relation to this presentation, the following COI to be disclosed: JSPS 2017 & 7th ISSBA Conflict of Interest Disclosure 　 Main author：　XXXX XXXX In relation to this presentation, the following COI to be disclosed: (1) Board member or Advisor of company： None / Company name (2) Profit of stock： None / Company name (3) Patient royalty： None / Company name (4) Lecture fees： None / Company name (5) Manuscript fees： None / Company name (6) Research expenses： None / Company name (7) Presents or any other payment： None / Company name 1