by Laura V. Blanton, Michael J. Barratt, Mark R

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Presentation transcript:

Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics by Laura V. Blanton, Michael J. Barratt, Mark R. Charbonneau, Tahmeed Ahmed, and Jeffrey I. Gordon Science Volume 352(6293):1533-1533 June 24, 2016 Published by AAAS

The concept that impaired postnatal gut microbiota development (maturation) is causally related to childhood undernutrition. The concept that impaired postnatal gut microbiota development (maturation) is causally related to childhood undernutrition. The representation of age-discriminatory bacterial taxa defines a program of normal gut microbiota development. Disrupting the coordinated functional codevelopment of microbiota and host affects multiple biological regulatory systems through largely unknown mechanisms. Developing effective strategies for sustained repair of microbiota immaturity though food or microbial interventions requires preclinical studies of these mechanisms and modeling of the effects of different rates and routes of repair. Laura V. Blanton et al. Science 2016;352:1533 Published by AAAS