Pushing the Envelope in Psoriasis: Late Cornified Envelope Proteins Possess Antimicrobial Activity  Nathan K. Archer, Migena N. Dilolli, Lloyd S. Miller  Journal of Investigative Dermatology  Volume 137, Issue 11, Pages 2257-2259 (November 2017) DOI: 10.1016/j.jid.2017.08.026 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Antimicrobial activity of LCE proteins in normal skin and psoriasis. (a) Compared with normal skin (wt/wt), the skin from individuals with the LCE3B/C-del has constitutive expression of LCE3A, which has antimicrobial activity against bacteria in the skin microbiome. (b) In lesional psoriasis skin, wt/wt individuals have markedly increased expression of LCE3A, LCE3B, and LCE3C, whereas individuals with the LCE3B/C-del only have upregulated LCE3A. All have broad-spectrum antimicrobial activity against bacteria in the skin microbiome. Altered self or microbial antigen exposure in the setting of LCE3B/C-del might elicit HLA-C*06:02 restricted immune responses, providing an explanation for the epistatic relationship between these two psoriasis gene susceptibility loci. LCE, late cornified envelope. Journal of Investigative Dermatology 2017 137, 2257-2259DOI: (10.1016/j.jid.2017.08.026) Copyright © 2017 The Authors Terms and Conditions