KCNA1 1.5 1.0 0.5 a KCNA2 * * b KCNAB1 1.5 1.0 0.5 c KCNB2 d

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Figure S4: Effects of METH SA on potassium channel mRNA expression in the dorsal striatum KCNA1 1.5 1.0 0.5 ** a KCNA2 *** * b KCNAB1 1.5 1.0 0.5 c KCNB2 d KCNMA1 1.5 1.0 0.5 e KCNN1 f (relative to control) Fold changes KCNN3 Control SR SS 1.5 1.0 0.5 h KCNN2 g Control SR SS Effects of METH SA on DNA hydroxymethylation and expression of potassium channels in the dorsal striatum. ( a-h) mRNA expression of potassium channels in abstinent (SS) and compulsive (SR) METH takers. Key to statistics: * P < 0.05 ; * *P < 0.01; * **P < 0.001 in comparison to control