L.-T. Wu, S.-W. Hung, Y.-C. Chuang, H.-E. Chen, R.N. Jones, W.-L. Yu

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Identification of a novel cephalosporinase (DHA-3) in Klebsiella pneumoniae isolated in Taiwan L.-T. Wu, S.-W. Hung, Y.-C. Chuang, H.-E. Chen, R.N. Jones, W.-L. Yu Clinical Microbiology and Infection Volume 11, Issue 11, Pages 893-897 (November 2005) DOI: 10.1111/j.1469-0691.2005.01252.x Copyright © 2005 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Example of results obtained with double-disk antagonism tests. ATM, aztreonam; CAZ, ceftazidime; CTX, cefotaxime; FEP, cefepime; FOX, cefoxitin. Clinical Microbiology and Infection 2005 11, 893-897DOI: (10.1111/j.1469-0691.2005.01252.x) Copyright © 2005 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Alignment of deduced amino-acid sequences of DHA-3 from Klebsiella pneumoniae KP3 with those of DHA-1 from Salmonella Enteritidis [7] and DHA-2 from K. pneumoniae 45956 [9]. Identical amino-acids are marked with dashes. The underlined amino-acids are those that may be involved in the catalytic site of these AmpC enzymes, including the β-lactamase active site S–V–S–K and the conserved triad K–T–G. Clinical Microbiology and Infection 2005 11, 893-897DOI: (10.1111/j.1469-0691.2005.01252.x) Copyright © 2005 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 3 Comparison of the alignment of the deduced amino-acid sequence of the AmpR protein of Klebsiella pneumoniae KP3 (Kp) with that of Morganella morganii (Mm) [14]. Clinical Microbiology and Infection 2005 11, 893-897DOI: (10.1111/j.1469-0691.2005.01252.x) Copyright © 2005 European Society of Clinical Infectious Diseases Terms and Conditions