Allotype Analysis to Distinguish the Origin of Varicella-Zoster Virus Immunoglobulin G after Allogeneic Stem Cell Transplantation Rie Yamazaki, Hideki.

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Allotype Analysis to Distinguish the Origin of Varicella-Zoster Virus Immunoglobulin G after Allogeneic Stem Cell Transplantation Rie Yamazaki, Hideki Nakasone, Yukie Tanaka, Miki Sato, Kiriko Terasako, Hidenori Wada, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Tomohito Machishima, Shun-ichi Kimura, Misato Kikuchi, Shinya Okuda, Shinichi Kako, Junya Kanda, Aki Tanihara, Junji Nishida, Yoshinobu Kanda Biology of Blood and Marrow Transplantation Volume 19, Issue 7, Pages 1013-1020 (July 2013) DOI: 10.1016/j.bbmt.2013.04.007 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Serial changes in donor-derived (A) and recipient-derived (B) IgG1m(f) levels after allogeneic HSCT. Expression of the IgG1m(f) allotype was evaluated by an ELISA assay using anti-IgG1m(f) antibody. The Y-axis shows the cut-off index (COI) that was calculated as the mean OD405 from a sample divided by the cut-off value defined as the mean OD405 from negative controls plus 2-fold standard deviation. Biology of Blood and Marrow Transplantation 2013 19, 1013-1020DOI: (10.1016/j.bbmt.2013.04.007) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Sequential changes in measles-specific (left) and varicella-zoster virus (VZV)-specific (right) IgG levels before and at 6 and 12 months after hematopoietic stem cell transplantation (HSCT). Triangles (measles) and circles (VZV) show individual data points. Mean values are shown by black lines. P values represent Jonckheere-Terpstra test. (B) The reduction rate at 6 (left) and 12 months (right) after HSCT. Box plots show the 25th and 75th percentiles and median values. P values represent nonparametric Wilcoxon signed rank test. Biology of Blood and Marrow Transplantation 2013 19, 1013-1020DOI: (10.1016/j.bbmt.2013.04.007) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Sequential changes in measles-specific (A) and varicella-zoster virus (VZV)-specific (B) donor-derived IgG1m(f) levels. Gray and black squares indicate patients with and without VZV disease, respectively. Black lines show the mean values at the same points. Biology of Blood and Marrow Transplantation 2013 19, 1013-1020DOI: (10.1016/j.bbmt.2013.04.007) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Clinical courses of the 4 IgG1m(f) homozygous-null patients (Patients 1 to 4) who underwent hematopoietic stem cell transplantation (HSCT) from IgG1m(f)-positive donors and developed varicella-zoster virus (VZV) disease after HSCT. Broken lines show VZV IgG1m(f) levels. CsA indicates cyclosporine; PSL, prednisolone; ACV, acyclovir; VCV, valacyclovir; GCV, ganciclovir. Biology of Blood and Marrow Transplantation 2013 19, 1013-1020DOI: (10.1016/j.bbmt.2013.04.007) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions