Figure 2 Muscle histology and morphometric analysis demonstrating muscle fiber hypertrophy, occasional internalized nuclei and slight irregularity in the.

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Figure 2 Muscle histology and morphometric analysis demonstrating muscle fiber hypertrophy, occasional internalized nuclei and slight irregularity in the muscle fiber intermyofibrillar network Muscle histology and morphometric analysis demonstrating muscle fiber hypertrophy, occasional internalized nuclei and slight irregularity in the muscle fiber intermyofibrillar network (A) Muscle fiber hypertrophy affecting both type 1 fibers (dark) and type 2 fibers (unstained) (adenosine triphosphatase, pH 4.3). (B) Muscle fiber hypertrophy and some internalized nuclei (hematoxylin and eosin). (C) Muscle fiber hypertrophy and patchy irregularities of the intermyofibrillar network (NADH-tetrazolium reductase). (D) Results from morphometric analysis. The lesser inner diameters (micrometers) of type 1 and type 2 fibers of 100 adjacent muscle fibers were measured in 4 different muscle biopsies from individuals II:1 and II:2 at different ages. Measurement of the lesser inner diameter avoids the risk of errors caused by oblique sections and was also used in the previously published measurements on controls that were used as references in this study.7 The results are given as medians, quartiles, and range. The median is at the border between the red and green boxes. The top of the green box is the 75th percentile of the sample, and the bottom of the red box is the 25th percentile. Normal mean diameters in age-matched controls are indicated with asterisks. Child controls included both males and females, and adult controls included females only. 1 = type 1 fibers; 2 = type 2 fibers. Carola Hedberg-Oldfors et al. Neurol Genet 2018;4:e254 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.