Effect of Statins on Kidney Disease Outcomes: A Systematic Review and Meta-analysis Xiaole Su, MD, Lu Zhang, MD, Jicheng Lv, MD, PhD, Jinwei Wang, PhD,

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Effect of Statins on Kidney Disease Outcomes: A Systematic Review and Meta-analysis Xiaole Su, MD, Lu Zhang, MD, Jicheng Lv, MD, PhD, Jinwei Wang, PhD, Wanyin Hou, MD, Xinfang Xie, MD, Hong Zhang, MD, PhD American Journal of Kidney Diseases Volume 67, Issue 6, Pages 881-892 (June 2016) DOI: 10.1053/j.ajkd.2016.01.016 Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Identification process for eligible studies. ∗Searching on ClinicalTtrials.gov and references. American Journal of Kidney Diseases 2016 67, 881-892DOI: (10.1053/j.ajkd.2016.01.016) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Forest plot for kidney failure events. Abbreviations and definitions: CI, confidence interval; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; PPP, Pravastatin Pooling Project (PPP) Study, including CARE, LIPID, and WOSCOPS studies, is a subgroup analysis of patients in the 3 studies; Scr, serum creatinine. American Journal of Kidney Diseases 2016 67, 881-892DOI: (10.1053/j.ajkd.2016.01.016) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Forest plot for rate of change in estimated glomerular filtration rate (eGFR). Positive values in difference of change represent slower decline for eGFR in statin group than in control group. Abbreviations: CI, confidence interval; MD, mean difference; SD, standard deviation. American Journal of Kidney Diseases 2016 67, 881-892DOI: (10.1053/j.ajkd.2016.01.016) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Forest plot for change in proteinuria or albuminuria. Negative values in difference of change represent greater decreases for proteinuria or albuminuria in statin group than in control group. Abbreviations: ACR, albumin-creatinine ratio; CI, confidence interval; PCR, protein-creatinine ratio; SD, standard deviation; SMD, standard mean difference; UAE, urinary albumin excretion; UPE, urinary protein excretion. American Journal of Kidney Diseases 2016 67, 881-892DOI: (10.1053/j.ajkd.2016.01.016) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions