Non-invasive measurement of renal perfusion and oxygen metabolism to predict postoperative acute kidney injury in neonates and infants after cardiopulmonary.

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Presentation transcript:

Non-invasive measurement of renal perfusion and oxygen metabolism to predict postoperative acute kidney injury in neonates and infants after cardiopulmonary bypass surgery F. Neunhoeffer, M. Wiest, K. Sandner, H. Renk, E. Heimberg, C. Haller, M. Kumpf, C. Schlensak, M. Hofbeck British Journal of Anaesthesia Volume 117, Issue 5, Pages 623-634 (November 2016) DOI: 10.1093/bja/aew307 Copyright © 2016 The Author(s) Terms and Conditions

Fig 1 CONSORT diagram. AKI, acute kidney injury; CHD, congenital heart disease; CPB, cardiopulmonary bypass; ECMO, extracorporeal membrane oxygenation. British Journal of Anaesthesia 2016 117, 623-634DOI: (10.1093/bja/aew307) Copyright © 2016 The Author(s) Terms and Conditions

Fig 2 Oxgen-to-See (O2C) device consists of a multiple-channel system, combining tissue spectrometry and laser Doppler flowmetry. Tissue photo spectrometry (TPS), oxygen saturation of hemoglobin (SO2), relative hemoglobin amount (rel Hb) and frequency (f). British Journal of Anaesthesia 2016 117, 623-634DOI: (10.1093/bja/aew307) Copyright © 2016 The Author(s) Terms and Conditions

Fig 3 Postoperative renal regional oxygen saturation ( r S O 2 ), microcirculation (rFlow), renal oxygen consumption (aRMRO2), and renal resistance index (RRI) in patients after surgical repair without acute kidney injury (AKI; Group 1), patients after surgical repair who developed AKI (Group 2), patients with surgical palliation without AKI (Group 3), and patients with surgical palliation who developed AKI (Group 4). *P-values <0.05 were considered statistically significant. The y-axis does not start at zero; the absolute differences may therefore appear larger than they really are. British Journal of Anaesthesia 2016 117, 623-634DOI: (10.1093/bja/aew307) Copyright © 2016 The Author(s) Terms and Conditions

Fig 4 Renal resistance index (RRI) of 1.0 in a female neonate after cardiac surgery with cardiopulmonary bypass. British Journal of Anaesthesia 2016 117, 623-634DOI: (10.1093/bja/aew307) Copyright © 2016 The Author(s) Terms and Conditions

Fig 5 Receiver operating characteristic curves of postoperative renal regional oxygen saturation ( r S O 2 ), microcirculation (rFlow), renal oxygen consumption (aRMRO2), and renal resistance index (RRI) for prediction of AKI. British Journal of Anaesthesia 2016 117, 623-634DOI: (10.1093/bja/aew307) Copyright © 2016 The Author(s) Terms and Conditions