Linking gene expression, nuclear factor kappa B, remote ischemic preconditioning, and transplantation: A quest for an elusive Holy Grail or a road to.

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Presentation transcript:

Linking gene expression, nuclear factor kappa B, remote ischemic preconditioning, and transplantation: A quest for an elusive Holy Grail or a road to an amazing discovery? Igor E. Konstantinov, MD, PhD, Andrew N. Redington, MD The Journal of Thoracic and Cardiovascular Surgery Volume 131, Issue 2, Pages 507-509 (February 2006) DOI: 10.1016/j.jtcvs.2005.07.043 Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Innate immunity pathways and NF κB. Remote ischemic preconditioning stimulus upregulates (red) and downregulates (green) gene expression of intracellular inflammatory pathways. HSP, Heat shock protein; LPS, lipopolysaccharide; LBP, LPS binding protein; TLR, toll-like receptor; IRAK, interleukin (IL)-1 receptor associated kinase; TIR, toll/IL-1/plan R homology domain; IKK, I-κB kinase; MnSOD, manganese superoxide dismutase. (From Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, et al. The Remote Ischemic Preconditioning Stimulus Modifies Inflammatory Gene Expression in Humans. Physiol Genomics. 2004;19:143-50; used with permission of The American Physiological Society.) The Journal of Thoracic and Cardiovascular Surgery 2006 131, 507-509DOI: (10.1016/j.jtcvs.2005.07.043) Copyright © 2006 The American Association for Thoracic Surgery Terms and Conditions