Airway and serum biochemical correlates of refractory neutrophilic asthma Rafeul Alam, MD, PhD, James Good, MD, Donald Rollins, MD, Mukesh Verma, PhD,

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Airway and serum biochemical correlates of refractory neutrophilic asthma Rafeul Alam, MD, PhD, James Good, MD, Donald Rollins, MD, Mukesh Verma, PhD, HongWei Chu, MD, Tuyet-Hang Pham, MT, Richard J. Martin, MD Journal of Allergy and Clinical Immunology Volume 140, Issue 4, Pages 1004-1014.e13 (October 2017) DOI: 10.1016/j.jaci.2016.12.963 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Journal of Allergy and Clinical Immunology 2017 140, 1004-1014 Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A-D, Comparison of blood and BAL fluid neutrophil counts among infection-positive (Inf+) and infection-negative (Inf−) patients with RA and patients with NRA, including and excluding patients with RA taking OCSs. Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of biomolecule levels between serum and BAL fluid among infection-positive (Inf+) patients with RA, infection-negative (Inf−) patients with RA, and patients with NRA. Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Comparison of systemic inflammatory markers in serum from infection-positive (Inf+) patients with RA, infection-negative (Inf−) patients with RA, and patients with NRA. Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Study design and overview of the results. A, Schematic presentation of study design. B, Inserted table summarizes the number of biomolecules studied, not detected, changed, and unchanged in BAL fluid and serum from the study subjects. C, Number of biomolecules in BAL fluid that were significantly (P < .05) different among study populations. Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Fold increase in biomolecule level in patients with RA compared with those with NRA (A and B). Patients with RA were subgrouped as having infection (infection positive, black bars) or no infection (infection negative, gray bars). Results in Fig E2, A, were separated from results in Fig E2, B, because of the higher level of increase (see labels on x-axis). Journal of Allergy and Clinical Immunology 2017 140, 1004-1014.e13DOI: (10.1016/j.jaci.2016.12.963) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions