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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.204 Figure 2 Features of antibody structure important for biosimilar cytotoxic effects Figure 2 | Features of antibody structure important for biosimilar cytotoxic effects. a | The basic structure of an IgG antibody contains a light chain with a variable and constant region and a heavy chain with a variable region, a hinge and three constant region domains, each with different functions. The glycan is attached to Asn297 in the CH2 domain. b | The antibody glycan contains a core heptasaccharide with four N- acetylglucosamine and three mannose residues. Human antibodies may contain a bisecting N-acetylglucosamine, but this structure is not as common in other species. Fucose and galactose residues are added heterogeneously. Sialic acid is only added on structures with galactose. Nikolov, N. P. & Shapiro, M. A. (2016) An FDA perspective on the assessment of proposed biosimilar therapeutic proteins in rheumatology Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.204