A major non-HLA locus in celiac disease maps to chromosome 191

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A major non-HLA locus in celiac disease maps to chromosome 191 Martine J Van Belzen, Jos W.R Meijer, Lodewijk A Sandkuijl, Alfons F.J Bardoel, Chris J.J Mulder, Peter L Pearson, Roderick H.J Houwen, Cisca Wijmenga Gastroenterology Volume 125, Issue 4, Pages 1032-1041 (October 2003) DOI: 10.1016/S0016-5085(03)01205-8

Figure 1 Maximum lod scores from the multipoint linkage analysis present on each chromosome in the initial genome-wide screen in 67 families. The horizontal line indicates a nominal significance threshold of 0.01. All regions reaching this threshold were further investigated in a follow-up study. Gastroenterology 2003 125, 1032-1041DOI: (10.1016/S0016-5085(03)01205-8)

Figure 2 Distribution of MLS values after fine mapping of the candidate regions on chromosomes 1, 5, 6, 8, 19, and 20 in the initial 67 families (thick line) and in all 82 families (thin line). The triangular symbols denote the positions of the markers on the chromosomes. Chromosome 2 is also included in this Figure because of its possible implication in celiac disease. The CELIAC3 region was only genotyped in the initial 67 families. Gastroenterology 2003 125, 1032-1041DOI: (10.1016/S0016-5085(03)01205-8)