Annie Wester, MD, MS, Jennifer T. Eyler, MD, James W. Swan, MD

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Topical imiquimod for the palliative treatment of recurrent oral squamous cell carcinoma Annie Wester, MD, MS, Jennifer T. Eyler, MD, James W. Swan, MD JAAD Case Reports Volume 3, Issue 4, Pages 329-331 (July 2017) DOI: 10.1016/j.jdcr.2017.04.008 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Computed tomography scan of the primary tumor on the neck soft tissue with contrast taken in 2006. A 1-cm soft tissue density is seen in the right retromolar trigone with a suggestion of minimal adjacent osseous erosion. The lesion is partially obscured by a metallic spray artifact secondary to the dental amalgam. JAAD Case Reports 2017 3, 329-331DOI: (10.1016/j.jdcr.2017.04.008) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histologic image of first recurrence demonstrating invasive moderately differentiated squamous cell carcinoma with extensive involvement of the underlying mandibular bone (Hematoxylin-eosin stain; original magnification: ×10.) JAAD Case Reports 2017 3, 329-331DOI: (10.1016/j.jdcr.2017.04.008) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Histologic image of second recurrence demonstrating a fragment of moderately differentiated squamous cell carcinoma (high power). Because of the fragmented and superficial nature of the specimen, the presence of invasion could not be definitively determined. (Hematoxylin-eosin stain; original magnification: ×40.) JAAD Case Reports 2017 3, 329-331DOI: (10.1016/j.jdcr.2017.04.008) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Right retromandibular trigone with no signs of recurrence. JAAD Case Reports 2017 3, 329-331DOI: (10.1016/j.jdcr.2017.04.008) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions