Figure 1 Treat to target, remission and low disease activity in SLE Figure 1 | Treat to target, remission and low disease activity in SLE. Control of active disease in systemic lupus erythematosus (SLE) can be conceived as concentric circles of progressively improving treatment response states associated with stepwise improvements in outcome, representing a continuum along which treatment can be directed. Rates of damage accrual will be lower at each stage of disease control, theoretically reaching zero for complete off-treatment remission. LLDAS, lupus low disease activity state. Morand, E. F. (2016) Remission in SLE — are we there yet? Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.174