I.V. acetaminophen pharmacokinetics in neonates after multiple doses

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I.V. acetaminophen pharmacokinetics in neonates after multiple doses G.M. Palmer, M. Atkins, B.J. Anderson, K.R. Smith, T.J. Culnane, C.M. McNally, E.J. Perkins, G.A. Chalkiadis, R.W. Hunt  British Journal of Anaesthesia  Volume 101, Issue 4, Pages 523-530 (October 2008) DOI: 10.1093/bja/aen208 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 The relationship between PMA and individual Bayesian acetaminophen CL estimates. British Journal of Anaesthesia 2008 101, 523-530DOI: (10.1093/bja/aen208) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 The relationship between unconjugated bilirubin and CL. CL was reduced in the presence of unconjugated bilirubin. British Journal of Anaesthesia 2008 101, 523-530DOI: (10.1093/bja/aen208) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Median time–concentration profile for neonates 34–46 weeks PMA without hyperbilirubinaemia given a single dose 15 mg kg−1. The 95% prediction interval is also shown. British Journal of Anaesthesia 2008 101, 523-530DOI: (10.1093/bja/aen208) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Predicted time–concentration profiles in neonates at 40 weeks PMA with two regular 6 h dosing regimens of 7.5 and 15 mg kg−1. British Journal of Anaesthesia 2008 101, 523-530DOI: (10.1093/bja/aen208) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 5 Graphs depicting changes in patients’ LFTs in relation to the time of their first dose of i.v. acetaminophen. The thick line represents the 80% bandwidth lowess curve fitted to each plot. Normal values for these LFTs (except unconjugated bilirubin) are indicated by the thin horizontal line. British Journal of Anaesthesia 2008 101, 523-530DOI: (10.1093/bja/aen208) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

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